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chloroquine

Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda

November 17, 2011 - 11:18 -- Kabogo Ndegwa
Author(s): 
Irene Zeile, Jean-Bosco Gahutu, Cyprien Shyirambere, Christian Steininger, Andre Musemakweri, Fidèle Sebahungu, Corine Karema, Gundel Harms, Teunis A. Eggelte, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 121, Issue 1, January 2012, Pages 50-54

MalariaWorldIn Rwanda, frequent mutations in the pfdhfr and pfdhps genes of Plasmodium falciparum have suggested intense sulfadoxine–pyrimethamine resistance.

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Molecular monitoring of Plasmodium falciparum resistance to antimalarial drugs after adoption of sulfadoxine–pyrimethamine plus artesunate as the first line treatment in Iran

November 17, 2011 - 11:09 -- Kabogo Ndegwa
Author(s): 
Mandana Afsharpad, Sedigheh Zakeri, Sakineh Pirahmadi, Navid Dinparast Djadid
Reference: 
Acta Tropica, Volume 121, Issue 1, January 2012, Pages 13-18

MalariaWorldThe main objective of this investigation was whether the combination therapy of sulfadoxine pyrimethamine (SP) plus artesunate (AS) protects against the spread of resistance to SP in malaria-endemic south-eastern Iran.

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Short Report: Distribution Pattern of Plasmodium falciparum Chloroquine Transporter (pfcrt) Gene Haplotypes in Sri Lanka 1996–2006

November 3, 2011 - 09:54 -- Patrick Sampao
Author(s): 
Jenny J. Zhang., Tharanga N. Senaratne., Nadira D. Karunaweera., et al
Reference: 
Am J Trop Med Hyg 2011 85:811-814

MalariaWorldWe examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72–76) haplotypes in Sri Lanka in 1996–1998 and 2004–2006 using a high-resolution melting assay.

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Role of Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes on In Vitro Chloroquine Resistance in Isolates of Plasmodium falciparum from Thailand

October 10, 2011 - 08:43 -- Patrick Sampao
Author(s): 
Chavachol Setthaudom, Peerapan Tan-ariya, Naruemon Sitthichot,Rommanee Khositnithikul, Nantana Suwandittakul, Saovanee Leelayoova and Mathirut Mungthin
Reference: 
Am J Trop Med Hyg 2011 85:606-611

MalariaWorldThus, we evaluated the influence of pfcrt and pfmdr1 polymorphisms on in vitro chloroquine sensitivity in 89 adapted isolates of P. falciparum from Thailand. We found that 87 of 89 isolates contained the CVIET haplotype of the pfcrt gene.

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Three unusual presentations of plasmodium vivax malaria

September 28, 2011 - 06:50 -- Kabogo Ndegwa
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Author(s): 
Satyendra Kumar Sonkar, Ravi Uniyal, and Gyanendra Kumar Sonkar
Reference: 
Trop Doct October 2011 vol. 41 no. 4 240-241

We present three cases of unusual and complicated malaria caused by Plasmodium vivax.

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Open Access | Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine

August 24, 2011 - 09:24 -- Kabogo Ndegwa
Author(s): 
Kritsiriwuthinan K, Chaotheing S, Shaw PJ, Wongsombat C, Chavalitshewinkoon-Petmitr P, Kamchonwongpaisan S
Reference: 
Malaria Journal 2011, 10:242 (18 August 2011)

The malaria parasite's molecular responses to PN and CQ treatment are similar in terms of the genes and pathways affected.

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Ex Vivo Drug Susceptibility of Ferroquine against Chloroquine-Resistant Isolates of Plasmodium falciparum and P. vivax

August 18, 2011 - 15:09 -- Patrick Sampao
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Ric N. Price, et al.
Reference: 
Antimicrobial Agents and Chemotherapy, September 2011,p. 4461-4464, Vol. 55, No. 9

In the current study, ex vivo FQ activity was tested in multidrug-resistant P. falciparum and P. vivax field isolates using a schizont maturation assay.

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Open Access | Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

August 3, 2011 - 06:50 -- Kabogo Ndegwa
Author(s): 
Dow GS, Gettayacamin M, Hansukjariya P, Imerbsin R, Komcharoen S, Sattabongkot J, Kyle D, Milhous W, Cozens S, Kenworthy D, Miller A, Veazey J, Ohrt C
Reference: 
Malaria Journal 2011, 10:212 (29 July 2011)

Ten-fold lower clinical doses of tafenoquine than used in prior studies may be effective against P. vivax hypnozoites if the drug is deployed in combination with effective blood-schizonticidal drugs.

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Efficacy of Chloroquine and Sulphadoxine-Pyrimethamine either alone or in combination before introduction of ACT as first-line therapy in uncomplicated Plasmodium falciparum malaria in Jalpaiguri District, West Bengal, India

July 13, 2011 - 08:10 -- Kabogo Ndegwa
Author(s): 
Shrabanee Mullick, Sonali Das, Ardhendu K. Maji, et al.
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 8, pages 929–935, August 2011

In Jalpaiguri District the overall failure rate of CQ was 61% and of SP 14%, which was well above the WHO recommended cut-off threshold level (10%) for change of drug policy.

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Open Access | Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro

July 12, 2011 - 07:53 -- Kabogo Ndegwa
Author(s): 
Kwansa-Bentum B, Ayi I, Suzuki T, Otchere J, Kumagai T, Anyan WK, Osei JH, Asahi H, Ofori MF, Akao N, Wilson MD, Boakye DA, Ohta N
Reference: 
Malaria Journal 2011, 10:187 (11 July 2011)

The pfATPase6 gene is highly polymorphic with D639G appearing to be fixed in Ghanaian isolates.

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