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chloroquine

Open Access | Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure

January 12, 2012 - 07:56 -- Kabogo Ndegwa
Author(s): 
Mallick PK, Joshi H, Valecha N, Sharma SK, Eapen A, Bhatt RM, Srivastava HC, Sutton PL, Dash AP, Bhasin VK
Reference: 
Malaria Journal 2012, 11:16 (11 January 2012)

MalariaWorldThe wild type pfcrt gene is linked to chloroquine sensitivity; however, presence of mutation cannot explain the therapeutic efficacy of CQ in the current scenario of chloroquine resistance.

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In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

January 11, 2012 - 08:34 -- Kabogo Ndegwa
Author(s): 
Eugénie Aimée Madiesse Kemgne, Wilfred Fon Mbacham, Fabrice Fekam Boyom, Paul Henri Amvam Zollo, Etienne Tsamo & Philip J. Rosenthal
Reference: 
Parasitology Research, Volume 110, Number 1, 109-117

MalariaWorldAnnonaceae species, Uvariopsis congolana (leaf, stem), Polyalthia oliveri (stem bark), and Enantia chlorantha (stem, stem bark) with yields ranging from 0.33% to 4.60%.

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Open Access | Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum

January 11, 2012 - 08:15 -- Kabogo Ndegwa
Author(s): 
Poyomtip T, Suwandittakul N, Sitthichot N, Khositnithikul R, Tan-ariya P, Mungthin M
Reference: 
Malaria Journal 2012, 11:7 (5 January 2012)

MalariaWorldData from the present study put doubt regarding the pfnhe-1 gene as to whether it could be used as the suitable marker for QN resistance in Thailand.

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Open Access | Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America

December 21, 2011 - 11:06 -- Kabogo Ndegwa
Author(s): 
Jovel IT, Mejia RE, Banegas E, Piedade R, Alger J, Fontecha G, Ferrreira PE, Veiga MI, Enamorado IG, Bjorkman A, Ursing J
Reference: 
Malaria Journal 2011, 10:376 (19 December 2011)

MalariaWorldThe results indicate that P. falciparum from Honduras remain sensitive to chloroquine and sulphadoxine-pyrimethamine.

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Open Access | Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites

December 14, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Ploemen I, Behet M, Nganou-Makamdop K, van Gemert G, Bijker E, Hermsen C, Sauerwein R
Reference: 
Malaria Journal 2011, 10:350 (9 December 2011)

MalariaWorldPbGFP-Luccon parasites are a straightforward and valuable tool for comprehension of the biological and immunological principles underlying protection against malaria.

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Inhibitory Activity of Ferroquine, versus Chloroquine, against Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I In Vitro Assay.

December 9, 2011 - 08:29 -- Patrick Sampao
Author(s): 
Eyase FL, Akala HM, Johnson JD, Walsh DS.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):984-8.

MalariaWorldThese findings support the notion that FQ could be useful in treating persons with P. falciparum malaria.

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Open Access | Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali

November 29, 2011 - 09:52 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Doumbo S, Saye R, Beavogui AH, Traore B, Djimde A, Niangly A, Kayentao K, Diallo M, Doumbo OK, Thera MA
Reference: 
Malaria Journal 2011, 10:345 (24 November 2011)

MalariaWorldOptiMal-IT test revealed similar results when compared to microscopy which is considered the gold standard for malaria diagnostics.

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Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections

November 29, 2011 - 09:47 -- Kabogo Ndegwa
Author(s): 
Cátia Ramalhete, Filipa P. da Cruz, Dinora Lopes, Silva Mulhovo, Virgílio E. Rosário, Miguel Prudêncio, Maria-José U. Ferreira
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 24, 15 December 2011, Pages 7474-7481

MalariaWorldBioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-d-glucopyranoside (3) and kuguaglycoside A (4).

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Synthesis and antimalarial evaluation of novel isocryptolepine derivatives

November 29, 2011 - 09:31 -- Kabogo Ndegwa
Author(s): 
Louise R. Whittell, Kevin T. Batty, Rina P.M. Wong, Erin M. Bolitho, Simon A. Fox, Timothy M.E. Davis, Paul E. Murray
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 24, 15 December 2011, Pages 7519-7525

MalariaWorldA series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells).

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Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo

November 23, 2011 - 08:32 -- Kabogo Ndegwa
Author(s): 
Xiaofen Li, Zhengxiang He, Lili Chen, Yayong Li, Qinyan Li, Siting Zhao, Zhu Tao, Wen Hu, Li Qin & Xiaoping Chen
Reference: 
Parasitology Research, Volume 109, Number 6, 1519-1524, DOI: 10.1007/s00436-011-2427-z

MalariaWorldMany malaria-endemic areas are also associated with high rates of human immunodeficiency virus (HIV) infection.

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