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chloroquine

Open Access | Comparison of molecular tests for the diagnosis of malaria in Honduras

April 26, 2012 - 13:08 -- Kabogo Ndegwa
Author(s): 
Fontecha GA, Mendoza M, Banegas E, Poorak M, De Oliveira AM, Mancero T, Udhayakumar V, Lucchi NW, Mejia RE
Reference: 
Malaria Journal 2012, 11:119 (18 April 2012)

MalariaWorldMolecular tests are valuable tools for the confirmation of Plasmodium species and in detecting mixed infections in malaria endemic regions.

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Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores

April 19, 2012 - 07:57 -- Kabogo Ndegwa
Author(s): 
Koneni V. Sashidhara, Manoj Kumar, Ram K. Modukuri, Rajeev Kumar Srivastava, Awakash Soni, Kumkum Srivastava, Shiv Vardan Singh, J.K. Saxena, Harsh M. Gauniyal, Sunil K. Puri
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 9, 1 May 2012, Pages 2971–2981

MalariaWorldA series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized following new methodology developed in our laboratory.

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Death in an Adolescent Girl with Methemoglobinemia and Malaria

April 4, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Jhuma Sankar, Anshul Gupta, Sunit Pathak, and Nand K Dubey
Reference: 
J Trop Pediatr (2012) 58 (2): 154-156

MalariaWorldA 16-year-old girl working in a paint and dye-casting factory of aniline dyes presented to the emergency with cyanosis, fever and altered sensorium.

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Open Access | Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

March 22, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Katarzyna KINGA Modrzynska, Alison Creasey, Paul Hunt, et al.
Reference: 
BMC Genomics 2012, 13:106

MalariaWorldTo address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

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Open Access | Biological activities of nitidine, a potential anti-malarial lead compound

March 14, 2012 - 07:03 -- Kabogo Ndegwa
Author(s): 
Bouquet J, Rivaud M, Chevalley S, Deharo E, Jullian V, Valentin A
Reference: 
Malaria Journal 2012, 11:67 (9 March 2012)

MalariaWorldNitidine can be considered a potential anti-malarial lead compound. Its ability to complex haem and inhibit beta-haematin formation suggests a mechanism of action similar to that of chloroquine.

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Genetic backgrounds of the Plasmodium falciparum chloroquine resistant transporter (pfcrt) alleles in Pakistan

March 5, 2012 - 12:14 -- Patrick Sampao
Author(s): 
Wasiq Faraz Rawasia, Sankar Sridaran, Mohammad Asim Beg, et al.
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 2, March 2012, Pages 278-281

MalariaWorldThis study was undertaken to investigate the genetic background of the CQ resistant pfcrt haplotypes in Pakistan.

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Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria

February 22, 2012 - 14:27 -- Patrick Sampao
Author(s): 
H. Peyton, David
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 400-407(8)

MalariaWorldThis short review tells the story of how Reversed Chloroquine drugs (RCQs) were developed.

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Open Access | Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells

February 14, 2012 - 07:01 -- Kabogo Ndegwa
Author(s): 
Joseph Kim, M. L. Richard Yip, Xiaoming Shen, Hubert Li, Li-Yu Charlie Hsin, Samuel Labarge, Eileen L. Heinrich, Wendy Lee, Jianming Lu, Nagarajan Vaidehi
Reference: 
PLoS ONE 7(2): e31004

MalariaWorldDespite recent advances in targeted therapies, patients with pancreatic adenocarcinoma continue to have poor survival highlighting the urgency to identify novel therapeutic targets.

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Open Access | Editorial: How Do We Best Diagnose Malaria in Africa?

February 3, 2012 - 14:01 -- Patrick Sampao
Author(s): 
Philip J. Rosenthal
Reference: 
Am J Trop Med Hyg 2012 86:192-193

MalariaWorldIn this regard, the advent of rapid diagnostic tests (RDTs) for malaria is an important advance. Multiple immunochromatographic tests, incorporating a number of different parasite antigens and produced by many different manufacturers, are now available.

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Open Access | Diversity of Plasmodium falciparum Chloroquine Resistance Transporter (pfcrt) Exon 2 Haplotypes in the Pacific from 1959 to 1979

January 24, 2012 - 07:24 -- Kabogo Ndegwa
Author(s): 
Chim W. Chan, Rita Spathis, Dana M. Reiff, Stacy E. McGrath, Ralph M. Garruto, J. Koji Lum
Reference: 
PLoS ONE 7(1): e30213

MalariaWorldNearly one million deaths are attributed to malaria every year.

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