Molecular tests are valuable tools for the confirmation of Plasmodium species and in detecting mixed infections in malaria endemic regions.
A series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized following new methodology developed in our laboratory.
A 16-year-old girl working in a paint and dye-casting factory of aniline dyes presented to the emergency with cyanosis, fever and altered sensorium.
To address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.
Nitidine can be considered a potential anti-malarial lead compound. Its ability to complex haem and inhibit beta-haematin formation suggests a mechanism of action similar to that of chloroquine.
This study was undertaken to investigate the genetic background of the CQ resistant pfcrt haplotypes in Pakistan.
This short review tells the story of how Reversed Chloroquine drugs (RCQs) were developed.
Despite recent advances in targeted therapies, patients with pancreatic adenocarcinoma continue to have poor survival highlighting the urgency to identify novel therapeutic targets.
In this regard, the advent of rapid diagnostic tests (RDTs) for malaria is an important advance. Multiple immunochromatographic tests, incorporating a number of different parasite antigens and produced by many different manufacturers, are now available.
Nearly one million deaths are attributed to malaria every year.