The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10240 malaria professionals are enjoying the free benefits of MalariaWorld today

chloroquine

Review of pyronaridine anti-malarial properties and product characteristics

August 15, 2012 - 07:59 -- Kabogo Ndegwa
Author(s): 
Croft SL, Duparc S, Arbe-Barnes SJ, Craft J, Shin C, Fleckenstein L, Borghini-Fuhrer I, Rim H
Reference: 
Malaria Journal 2012, 11:270 (9 August 2012)

MalariaWorldPyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.

Country: 
Medical Condition: 
Medical Treatment: 

NOT Open Access | Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

July 24, 2012 - 11:54 -- Kabogo Ndegwa
Author(s): 
Dea Shahinas, Gregory MacMullin, Christan Benedict, Ian Crandall, and Dylan R. Pillai
Reference: 
Antimicrob. Agents Chemother. August 2012 vol. 56 no. 8 4207-4213

MalariaWorldPrevious studies have shown an antimalarial effect of total alkaloids extracted from leaves of Guiera senegalensis from Mali in West Africa.

Medical Condition: 
Medical Treatment: 

Not Open Access | Plasmodium vivax remains responsive to chloroquine with primaquine treatment regimen: a prospective cohort study from tertiary care teaching hospital in southern India

July 18, 2012 - 15:17 -- Patrick Sampao
Author(s): 
Kavitha Saravu, MD DNB, Vasudeva Acharya, MD DNB, Krishna Kumar, MD and Rishikesh Kumar, MSc MLT
Reference: 
Trop Doct July 2012 vol. 42 no. 3 163-164

We conducted this prospective study among 110 symptomatic Plasmodium vivax patients attending the Kasturba Hospital, Manipal, India, in order to evaluate their clinico-laboratory profile during July 2007–July 2009.

Country: 
Medical Condition: 
Medical Treatment: 

Not Open Access | Synthesis, characterization of chitosan–tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: A dose and duration dependent approach

July 18, 2012 - 14:32 -- Patrick Sampao
Author(s): 
Satyajit Tripathy, Sabyasachi Das, Subhankari Prasad Chakraborty, Sumanta Kumar Sahu, Panchanan Pramanik, Somenath Roy
Reference: 
International Journal of Pharmaceutics, Volume 434, Issues 1–2, 15 September 2012, Pages 292-305

In the study, the interaction of CS and TPP and the presence of chloroquine at the surface of chitosan–TPP NPs have been investigated by means of different methods like FTIR, DLS, and zeta potential.

Medical Condition: 
Medical Treatment: 

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

June 26, 2012 - 11:22 -- Kabogo Ndegwa
Author(s): 
Janni Papakrivos, Juliana M. Sá, Thomas E. Wellems
Reference: 
PLoS ONE 7(6): e39569

MalariaWorldIsolated vesicles from mutant-PfCRT-transformed D. discoideum exhibit features of the CQR phenotype, consistent with evidence that the drug resistance mechanism operates at the P. falciparum digestive vacuole membrane in malaria.

Medical Treatment: 

Not Open Access | Malaria drug resistance: new observations and developments.

June 18, 2012 - 15:18 -- Patrick Sampao
Author(s): 
Sá JM, Chong JL, Wellems TE.
Reference: 
Essays Biochem. 2011;51:137-60.

MalariaWorldWe review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine.

Medical Condition: 

NOT Open Access | Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones

June 6, 2012 - 07:26 -- Kabogo Ndegwa
Author(s): 
Deepa Ganesh, Hans-Peter Fuehrer, Peter Starzengrüber, Paul Swoboda, Wasif Ali Khan, Johannes A. B. Reismann, Milena S. K. Mueller, Peter Chiba & Harald Noedl
Reference: 
Parasitology Research, Volume 110, Number 6 (2012), 2289-2295

MalariaWorldMalaria is still a major threat in many parts of the world with resistance spreading to almost all classes of antimalarials.

Medical Condition: 
Medical Treatment: 

Synthesis and in vitro antiplasmodial activities of fluoroquinolone analogs

May 2, 2012 - 08:49 -- Kabogo Ndegwa
Author(s): 
Sandeep K. Dixit, Nidhi Mishra, Manish Sharma, Shailja Singh, Alka Agarwal, Satish K. Awasthi, V.K. Bhasin
Reference: 
European Journal of Medicinal Chemistry, Volume 51, May 2012, Pages 52–59

MalariaWorldFluoroquinolone analogs were synthesized by simple alkylation followed by click chemistry and evaluated for their antimalarial in vitro against chloroquine sensitive strain of Plasmodium falciparum while ciprofloxacin was used as standard.

Medical Condition: 
Medical Treatment: 

Open Access | Distribution of human CYP2C8*2 allele in three different African populations

May 2, 2012 - 07:44 -- Kabogo Ndegwa
Author(s): 
Paganotti GM, Gramolelli S, Tabacchi F, Russo G, Modiano D, Coluzzi M, Romano R
Reference: 
Malaria Journal 2012, 11:125 (25 April 2012)

MalariaWorldThis study demonstrated that CYP2C8*2 allele is widespread in Africa.

Continent: 
Medical Condition: 

Pages

Subscribe to RSS - chloroquine