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chloroquine

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000--2011

January 29, 2013 - 04:40 -- Open Access
Author(s): 
Gharbi M, Flegg J, Hubert V, Kendjo E, Metcalf JE, Bertaux L, Guérin PJ, Le Bras J
Reference: 
Malaria Journal 2013, 12:35 (25 January 2013)
MalariaWorld

The study was conducted by the Malaria National Reference Centre, France. The database collated the pfcrtK76T molecular marker for CQ susceptibility and the in vitro response to CQ of parasites from travellers' isolates returning from Senegal, Mali, Ivory Coast or Cameroon.

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Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region

January 9, 2013 - 15:02 -- Open Access
Author(s): 
Diego F Echeverry, Shalini Nair, Lyda Osorio, Sanjay Menon, Claribel Murillo and Tim JC Anderson
Reference: 
BMC Genetics 2013, 14:2
MalariaWorld

We conclude that Colombian populations have several advantages for association studies, because multiple clone infections are uncommon and LD decays over the scale of one or a few genes.

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NOT Open Access | Novel mutations in the antifolate drug resistance marker genes among Plasmodium vivax isolates exhibiting severe manifestations

November 26, 2012 - 13:05 -- NOT Open Access
Author(s): 
Shilpi Garg, Vishal Saxena, Ashis Das, et al.
Reference: 
Experimental Parasitology, Volume 132, Issue 4, December 2012, Pages 410–416
MalariaWorld

Plasmodium vivax is the predominant species of the human malaria parasite present in the Indian subcontinent. There have been recent reports on Chloroquine (CQ) resistance and severe manifestations shown by P. vivax from different regions of the world including India. This study focuses on Bikaner, India where during the last few years there have been continuous reports of severe manifestations by both Plasmodium falciparum and P. vivax.

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Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

November 25, 2012 - 14:02 -- Open Access
Author(s): 
Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ
Reference: 
Malaria Journal 2012, 11:382 (21 November 2012)
MalariaWorld

This paper describes the results of an anti-malarial activity-driven investigation of the fruits of this Cameroonian plant.

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Not Open Access | Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization

November 25, 2012 - 13:52 -- NOT Open Access
Author(s): 
K. NGANOU-MAKAMDOP, I. PLOEMEN, M. BEHET, G.-J. VAN GEMERT, C. HERMSEN, M. ROESTENBERG, R. W. SAUERWEIN
Reference: 
Parasite Immunology, Volume 34, Issue 12, pages 562–569, December 2012
MalariaWorld

We investigated in a murine model the protective efficacy and immune responses after ID or IV immunization of sporozoites.

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Assessment of the Molecular Marker of Plasmodium falciparum Chloroquine Resistance (Pfcrt) in Senegal after Several Years of Chloroquine Withdrawal

October 10, 2012 - 16:11 -- Patrick Sampao
Author(s): 
Magatte Ndiaye, Babacar Faye, Roger Tine, Jean Louis Ndiaye, Aminata Lo, Annie Abiola, Yemou Dieng, Daouda Ndiaye, Rachel Hallett, Michael Alifrangis and Oumar Gaye
Reference: 
Am J Trop Med Hyg 2012 87:640-645

MalariaWorldAfter several years of CQ withdrawal, the current study wished to determine the level of CQ resistance at the molecular level in selected sites in Senegal, because the scientific community is interested in using CQ again.

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Strain-Specific Protective Effect of the Immunity Induced by Live Malarial Sporozoites under Chloroquine Cover

October 1, 2012 - 07:57 -- Kabogo Ndegwa
Author(s): 
Wathsala Wijayalath, Sandra Cheesman, Kazuyuki Tanabe, Shiroma Handunnetti, Richard Carter, Sisira Pathirana
Reference: 
PLoS ONE 7(9): e45861

MalariaWorldThe efficacy of a whole-sporozoite malaria vaccine would partly be determined by the strain-specificity of the protective responses against malarial sporozoites and liver-stage parasites.

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NOT Open Access | Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds

September 3, 2012 - 07:48 -- Kabogo Ndegwa
Author(s): 
Lezanne van Heerden, Theunis T. Cloete, J. Wilma Breytenbach, Carmen de Kock, Peter J. Smith, Jaco C. Breytenbach, David D. N’Da
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 335–345

MalariaWorldSeries of bisquinolines 4–15 and bispyrrolo[1,2a]quinoxalines 16–20 containing various polyamine linkers were synthesized.

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A Longitudinal Trial Comparing Chloroquine as Monotherapy or in Combination with Artesunate, Azithromycin or Atovaquone-Proguanil to Treat Malaria

August 31, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Miriam K. Laufer, Phillip C. Thesing, Fraction K. Dzinjalamala, Osward M. Nyirenda, Rhoda Masonga, Matthew B. Laurens, Abbie Stokes-Riner, Terrie E. Taylor, Christopher V. Plowe
Reference: 
PLoS ONE 7(8): e42284.

MalariaWorldWe aimed to compare the ability of different partner drugs to preserve chloroquine efficacy and prevent the re-emergence of resistance.

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Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages

August 30, 2012 - 08:01 -- Kabogo Ndegwa
Author(s): 
Matthews H, Ali M, Carter V, Underhill A, Hunt J, Szor H, Hurd H
Reference: 
Malaria Journal 2012, 11:297 (28 August 2012)

MalariaWorldIt is proposed that both a mitochondrial and an amitochondrial apoptotic pathway may be involved, dependent upon the trigger that induces apoptosis, and that pathways may differ between erythrocytic stages and ookinetes, or between rodent and human malaria parasites.

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