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chloroquine

Open Access | Commentary: Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

December 29, 2010 - 11:48 -- Kabogo Ndegwa
Author(s): 
Sa JM, Twu O
Reference: 
Malaria Journal 2010, 9:374 (23 December 2010)

The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.

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In Vivo and In Vitro Efficacy of Chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia

December 28, 2010 - 09:45 -- Kabogo Ndegwa
Author(s): 
H. Siswantoro, B. Russell, A. Ratcliff, B. Prasetyorini, F. Chalfein, J. Marfurt, E. Kenangalem, M. Wuwung, K. A. Piera, E. P. Ebsworth, N. M. Anstey, E. Tjitra, and R. N. Price
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 197-202, Vol. 55, No. 1

Reports of potential drug-resistant strains of Plasmodium malariae in western Indonesia raise concerns that chloroquine resistance may be emerging in P. malariae and P. ovale.

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Open Access | Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment

November 24, 2010 - 09:12 -- Kabogo Ndegwa
Author(s): 
Won-Ja Lee, Hyung-Hwan Kim, Yien-Kyoung Choi, Kyung-Mi Choi, Mi-A Kim, Jung-Yeon Kim, Jetsumon Sattabongkot, Youngjoo Sohn, Hyuk Kim, Jong-Koo Lee, Han-Sook Park, Hyeong-Woo Lee
Reference: 
Malaria Journal 2010, 9:331 (18 November 2010)

These results suggest that sequence variations in the DHFR-TS represent the prevalence of antifolate-resistant P. vivax in Korea.

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Open Access | Oral Presentation: Progress in the development of Reversed Chloroquine molecules as antimalarial therapy

November 5, 2010 - 09:52 -- Patrick Sampao
Author(s): 
Steven J Burgess, Jane Xu-Kelly, Katherine Liebmann, Bornface Gunsaru, Westin Morrill, David H Peyton
Reference: 
Malaria Journal 2010, 9(Suppl 2):O6 (20 October 2010)

Chloroquine (CQ) resistance in P. falciparum is strongly linked to mutations in the gene pfcrt that gives rise to the protein, PfCRT (P. falciparum chloroquine resistance transporter), located in the parasite's digestive vacuole (DV) membrane [1].

Open Access | Factors determining anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya

October 30, 2010 - 12:14 -- Kabogo Ndegwa
Author(s): 
Watsierah CA, Jura WG, Oyugi H, Abong'o B, Ouma C
Reference: 
Malaria Journal 2010, 9:295 (26 October 2010)

This study demonstrates that consumers require access to correct and comprehensible information associated with use of drugs, including self-prescription.

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Review: Efficacy and safety of chloroquine for treatment in patients with uncomplicated Plasmodium vivax infections in endemic countries

October 22, 2010 - 09:55 -- Patrick Sampao
Author(s): 
Cho Naing, Kyan Aung, Daw-Khin Win, Mak Joon Wah
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 11, November 2010, Pages 695-705

The objective of this review is to summarize the existing evidence on the relative efficacy and safety of CQ in treating patients with uncomplicated P. vivax malaria in endemic countries.

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Open Access | Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar

October 17, 2010 - 14:45 -- Patrick Sampao
Author(s): 
Valérie A., Arsène R., et al.
Reference: 
PLoS ONE 5(10) e13281

These results highlight the limits of the current in vitro tests routinely used to monitor CQ drug resistance in this unique context. Gaining insight about the mechanisms that regulate polymorphism in Pfmdr1 remains important, particularly regarding the evolution and spread of Pfmdr-1 alleles in P. falciparum populations under changing drug pressure which may have important consequences in terms of antimalarial use management.

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Open Access | Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology

October 11, 2010 - 08:15 -- Kabogo Ndegwa
Author(s): 
Ballif M, Hii J, Marfurt J, Crameri A, Fafale A, Felger I, Beck H, Genton B
Reference: 
Malaria Journal 2010, 9:270 (6 October 2010)

This work provides the first insight into drug resistance markers of P. falciparum in the SI. The obtained results indicated the presence of a very homogenous P. falciparum population circulating in the community.

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Bis-alkylamine quindolone derivatives as new antimalarial leads

September 15, 2010 - 13:41 -- Patrick Sampao
Author(s): 
João L., Kaamil G., et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 19, 1 Oct 2010, Pg 5634-5637

Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine.

Open Access | Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections

August 20, 2010 - 13:59 -- Kabogo Ndegwa
Author(s): 
Daneshvar C, Davis TM, Cox-Singh J, Rafa'ee MZ, Zakaria SK, Divis PC, Singh B
Reference: 
Malaria Journal 2010, 9:238 (19 August 2010)

Chloroquine plus primaqine is an inexpensive and highly effective treatment for uncomplicated knowlesi malaria infections in humans and there is no evidence of drug resistance.

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