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chloroquine

Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome

March 1, 2011 - 06:25 -- Kabogo Ndegwa
Author(s): 
Rina P. M. Wong, Sam Salman, Kenneth F. Ilett, Peter M. Siba, Ivo Mueller, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 1194-1198, Vol. 55, No. 3

Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin.

Success in controlling a major outbreak of malaria because of Plasmodium falciparum in Jamaica

February 24, 2011 - 07:10 -- Kabogo Ndegwa
Author(s): 
Karen Webster-Kerr, J. Peter Figueroa, Sheila Campbell-Forrester, et al.
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 3, pages 298–306, March 2011

In 2006, after 44 years of eradication of malaria, Jamaica had an outbreak of Plasmodium falciparum: 406 confirmed cases between September 2006 and December 2009 with a peak of the epidemic in December 2006.

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Epidemic of Plasmodium falciparum malaria in Central India, an area where chloroquine has been replaced by artemisinin-based combination therapy

February 23, 2011 - 10:16 -- Patrick Sampao
Author(s): 
Neeru Singh., Man M. Shukla., Aditya P. Dash., et al.
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 105, Issue 3, March 2011, Pages 133-139

Evidence suggests that the non-availability of artemisinin-based combination therapy and rapid diagnostic tests along with an immunogenically vulnerable population each played an important role.

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Open Access | Resistance-mediating polymorphisms of Plasmodium falciparum among isolates from children with severe malaria in kumasi, ghana

February 22, 2011 - 07:59 -- Kabogo Ndegwa
Author(s): 
Abruquah H, Bio F, Tay S, Lawson B.
Reference: 
Ghana Medical Journal, Volume 44, Number 2

The study affirms Pfcrt as a better chloroquine resistance marker.

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Open Access | Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

February 17, 2011 - 06:42 -- Kabogo Ndegwa
Author(s): 
Chaijaroenkul W, Ward SA, Mungthin M, Johnson D, Owen A, Bray PG, Na-Bangchang K
Reference: 
Malaria Journal 2011, 10:42 (15 February 2011)

Data from the present study suggest that other genes must contribute to the degree of resistance once the resistance phenotype is established through mutations in pfcrt.

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Open Access | Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan

February 2, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ghanchi NK, Ursing J, Beg MA, Veiga MI, Jafri S, Martensson A
Reference: 
Malaria Journal 2011, 10:18 (28 January 2011)

The results indicate high prevalence of in vivo resistance to chloroquine, whereas high grade resistance to sulphadoxine-pyrimethamine does not appear to be widespread among P. falciparum in southern Pakistan.

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Open Access | Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs

January 19, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
Pascual A, Basco LK, Baret E, Amalvict R, Travers D, Rogier C, Pradines B
Reference: 
Malaria Journal 2011, 10:8 (14 January 2011)

The atmospheric generators for capnophilic bacteria Genbag CO2(R) is an appropriate technology that can be transferred to the field for epidemiological surveys of drug-resistant malaria.

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Confirmed Vivax Resistance to Chloroquine and Effectiveness of Artemether-Lumefantrine for the Treatment of Vivax Malaria in Ethiopia

January 10, 2011 - 07:55 -- Patrick Sampao
Author(s): 
Ambachew M. Yohannes, Awash Teklehaimanot, Yngve Bergqvist and Pascal Ringwald
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 137 - 140.

Chloroquine (CQ) is still the drug of choice for the treatment of vivax malaria in Ethiopia, whereas artemether-lumefantrine (AL) is for falciparum malaria. In this setting, clinical malaria cases are treated with AL.

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Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs

January 4, 2011 - 06:25 -- Kabogo Ndegwa
Author(s): 
Adriana Pabón, Eric Deharo, Silvia Blair
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 222-227

The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN).

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Open Access | Chloroquine-induced Pruritus

January 3, 2011 - 08:50 -- Kabogo Ndegwa
Author(s): 
SE Aghahowa, HO Obianwu, AO Isah, IM Arhewoh
Reference: 
Indian Journal of Pharmaceutical Sciences, 2010, Volume: 72, Issue: 3, Page: 283-289

Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies.

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