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Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

September 16, 2010 - 18:23 -- Ingeborg van Schayk
Richard K. Haynes Prof. Dr., Wing-Chi Chan, Ho-Ning Wong Dr., Ka-Yan Li, Wai-Keung Wu, Kit-Man Fan, Herman H. Y. Sung Dr., Ian D. Williams Prof. Dr., Davide Prosperi Dr., Sergio Melato Dr., Paolo Coghi Dr., Diego Monti Prof. Dr.
ChemMedChem Volume 5, Issue 8, pages 1282–1299, August 2, 2010

The antimalarial drug methylene blue (MB) affects the redox behaviour of parasite flavin-dependent disulfide reductases such as glutathione reductase (GR) that control oxidative stress in the malaria parasite.

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