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Dihydroflavins

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

September 16, 2010 - 18:23 -- Ingeborg van Schayk
Author(s): 
Richard K. Haynes Prof. Dr., Wing-Chi Chan, Ho-Ning Wong Dr., Ka-Yan Li, Wai-Keung Wu, Kit-Man Fan, Herman H. Y. Sung Dr., Ian D. Williams Prof. Dr., Davide Prosperi Dr., Sergio Melato Dr., Paolo Coghi Dr., Diego Monti Prof. Dr.
Reference: 
ChemMedChem Volume 5, Issue 8, pages 1282–1299, August 2, 2010

The antimalarial drug methylene blue (MB) affects the redox behaviour of parasite flavin-dependent disulfide reductases such as glutathione reductase (GR) that control oxidative stress in the malaria parasite.

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