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Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation

September 14, 2010 - 13:03 -- Patrick Sampao
Sara Finaurini, Luisa Ronzoni, Alessandra Colancecco, Alessandra Cattaneo, Maria Domenica Cappellini, Stephen A. Ward, Donatella Taramelli
Toxicology, Volume 276, Issue 2, 9 October 2010, Pages 128-134

This is the first demonstration that DHA affects human erythropoiesis in vitro, in a dose- and time-dependent manner; the target population seems to be the pro-erythroblast and basophilic erythroblast stage, suggesting that DHA toxicity is limited to primitive human erythropoiesis.

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