The Fever portrays the fight against malaria as a case study--in greed and courage. For The Fever Katharina Weingartner focuses on the complex history, present and future of malaria and observes the search for a solution. Could millions of deaths have been prevented, if ancient medical knowledge had been taken more seriously?
I am pleased to send you this brief summary of our most recent and interesting African Malaria Dialogue, held during a luncheon meeting on Wednesday 9 October at the Harvard School of Public Health in Boston.
In the search for new plant-derived anti-malarial compounds, chromatographic fractions of chloroform extract of whole plants of Artemisia maciverae were tested in vivo using chloroquine resistant and chloroquine sensitive Plasmodium berghei NK 65 infected Swiss albino mice.
Artemisinin, from which the artemether component of Coartem®(artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy. Artemisinin was first identified by Chinese researchers as the active anti-malarial constituent of A. annua and its derivatives were found to be the most potent of all anti-malarial drugs.