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Bioassay-guided fractionation and in vivo antiplasmodial effect of fractions of chloroform extract of Artemisia maciverae Linn

October 31, 2009 - 09:43 -- Ingeborg van Schayk
A.C. Ene, S.E. Atawodi, D.A. Ameh, G.I. Ndukwe, H.O. Kwanashie
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 288-294,doi:10.1016/j.actatropica.2009.08.016

In the search for new plant-derived anti-malarial compounds, chromatographic fractions of chloroform extract of whole plants of Artemisia maciverae were tested in vivo using chloroquine resistant and chloroquine sensitive Plasmodium berghei NK 65 infected Swiss albino mice.

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Review: Coartem®: the journey to the clinic

October 25, 2009 - 14:58 -- Bart G.J. Knols
Zulfiqarali G Premji
Malaria Journal 2009, 8(Suppl 1):S3 (12 October 2009)

Artemisinin, from which the artemether component of Coartem®(artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy. Artemisinin was first identified by Chinese researchers as the active anti-malarial constituent of A. annua and its derivatives were found to be the most potent of all anti-malarial drugs.


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