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tumor necrosis factor (TNF)

TNF family members and malaria: Old observations, new insights and future directions Original

September 8, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Louise M. Randall, Christian R. Engwerda
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 326-331

Tumor necrosis factor (TNF) has long been recognized to promote malaria parasite killing, but also to contribute to the development of severe malaria disease. The precise molecular mechanisms that influence these different outcomes in malaria patients are not well understood, but the virulence and drug-resistance phenotype of malaria parasites and the genetic background and age of patients are likely to be important determinants.

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