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arylpyrrolylaminoquinolines

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines

September 6, 2010 - 09:29 -- Patrick Sampao
Author(s): 
Manolo Casagrande, Nicoletta Basilico, Chiara Rusconi, Donatella Taramelli, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6625-6633

The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine.

Medical Treatment: 
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