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cassiarin

Synthesis and structure–activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity.

November 18, 2009 - 12:54 -- Kabogo Ndegwa
Author(s): 
Hiroshi Morita, Yuichiro Tomizawa, Jun Deguchi, Tokio Ishikawa, Hiroko Arai, Kazumasa Zaima, Takahiro Hosoya, Yusuke Hirasawa, Takayuki Matsumoto, Katsuo Kamata, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Toshio Honda.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 17, Issue 24, 15 December 2009, Pages 8234-8240, doi:10.1016/j.bmc.2009.10.013

Cassiarin A 1, a tricyclic alkaloid, isolated from the leaves of Cassia siamea (Leguminosae), shows powerful antimalarial activity against Plasmodium falciparum in vitro as well as P. berghei in vivo, which may be valuable leads for novel antimalarials.

Medical Treatment: 
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