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Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.

November 18, 2009 - 12:56 -- Kabogo Ndegwa
Martin Michaelis, Malte C. Kleinschmidt, Susanne Barth, Florian Rothweiler, Janina Geiler, Rainer Breitling, Bernd Mayer, Hedwig Deubzer, Olaf Witt, Jörg Kreuter, Hans Wilhelm Doerr, Jaroslav Cinatl, Jindrich Cinatl Jr.
Biochemical Pharmacology, Volume 79, Issue 2, 15 January 2010, Pages 130-136, doi:10.1016/j.bcp.2009.08.013

Artemisinin derivatives are well-tolerated anti-malaria drugs that also exert anti-cancer activity. Here, we investigated artemisinin and its derivatives dihydroartemisinin and artesunate in a panel of chemosensitive and chemoresistant human neuroblastoma cells as well as in primary neuroblastoma cultures.

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Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine.

November 18, 2009 - 12:53 -- Patrick Sampao
Iva Fernandes, Nuno Vale, Victor de Freitas, Rui Moreira, Nuno Mateus, Paula Gomes.
Bioorganic & Medicinal Chemistry Letters, Volume 19, Issue 24, 15 December 2009, Pages 6914-6917, doi:10.1016/j.bmcl.2009.10.081

The growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated.

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