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intermittent preventive treatment (IPT)

The perception of parents and teachers about intermittent preventive treatment for malaria in school children in a semi-rural area of Kinshasa, in the Democratic Republic of Congo

January 10, 2017 - 17:34 -- Open Access
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Author(s): 
Junior R. Matangila, Jessica Fraeyman, Hilde Bastiaens, et al.
Reference: 
Malaria Journal 2017 16:19, 7 January 2017

These results suggest that more efforts are needed to improve overall malaria-related knowledge in the community, specifically chemo-prevention strategies and the safety of the drugs used, to ensure the success of health interventions.

Scaling-up the use of sulfadoxine-pyrimethamine for the preventive treatment of malaria in pregnancy: results and lessons on scalability, costs and programme impact from three local government areas in Sokoto State, Nigeria

November 9, 2016 - 17:18 -- Open Access
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Author(s): 
Nosa Orobaton, Anne M. Austin, Katherine Beal, et al.
Reference: 
Malaria Journal 2016 15:533, 4 November 2016

It is feasible, safe, and affordable to scale up the delivery of high impact IPTp-SP interventions in low resource malaria endemic settings, where few women access facility-based maternal health services.

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Low-grade sulfadoxine–pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola

June 13, 2016 - 16:13 -- Open Access
Author(s): 
Elsa P. S. Kaingona-Daniel, Larissa Rodrigues Gomes, Maria de Fátima Ferreira-da-Cruz, et al.
Reference: 
Malaria Journal 2016 15:309, 7 June 2016

pfdhfr and pfdhps gene mutations in isolates from Lubango are suggestive of a low-grade SP resistance and IPT for pregnant women and infant based on SP treatment could be effective.

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Efficacy and safety of intermittent preventive treatment for malaria in schoolchildren: a systematic review

November 18, 2015 - 14:10 -- Open Access
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Author(s): 
Junior Matangila, Patrick Mitashi, Raquel Inocêncio da Luz, Pascal Lutumba, Jean-Pierre Van Geertruyden
Reference: 
Malaria Journal 2015, 14:450 (14 November 2015)

IPTsc may reduce the malaria-related burden in schoolchildren.

The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial

September 22, 2015 - 16:09 -- Open Access
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Author(s): 
Dominik Glinz, Richard Hurrell, Rita Wegmüller, et al.
Reference: 
Malaria Journal 2015, 14:347 (17 September 2015)

IPT alone only modestly decreased anaemia, but neither IPT nor iron fortified CF significantly improved Hb concentration after 9 months.

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NOT Open Access | Increasing Prevalence of a Novel Triple-Mutant Dihydropteroate Synthase Genotype in Plasmodium falciparum in Western Kenya

June 17, 2015 - 13:38 -- NOT Open Access
Author(s): 
Naomi W. Lucchi, Sheila Akinyi Okoth, Franklin Komino, Philip Onyona, Ira F. Goldman, Dragan Ljolje, Ya Ping Shi, John W. Barnwell, Venkatachalam Udhayakumar, and Simon Kariuki
Reference: 
Antimicrob. Agents Chemother. July 2015 vol. 59 no. 7 3995-4002

The molecular basis of sulfadoxine-pyrimethamine (SP) resistance lies in a combination of single-nucleotide polymorphisms (SNPs) in two genes coding for Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and P. falciparum dihydropteroate synthase (Pfdhps), targeted by pyrimethamine and sulfadoxine, respectively.

Submicroscopic malaria infection during pregnancy and the impact of intermittent preventive treatment

July 22, 2014 - 09:22 -- Open Access
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Author(s): 
Cohee LM, Kalilani-Phiri L, Boudova S, Joshi S, Mukadam R, Seydel KB, Mawindo P, Thesing P, Kamiza S, Makwakwa K, Muehlenbachs A, Taylor TE, Laufer MK
Reference: 
Malaria Journal 2014, 13 :274 (15 July 2014)

Submicroscopic malaria infection is common and occurs early in pregnancy.

NOT Open Access | Substantial increase in mutations in the genes pfdhfr and pfdhps puts sulphadoxine–pyrimethamine-based intermittent preventive treatment for malaria at risk in Burkina Faso

May 6, 2014 - 11:58 -- NOT Open Access
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Author(s): 
Carolin Geiger, Guillaume Compaore, Boubacar Coulibaly, Ali Sie, Martin Dittmer, Cecilia Sanchez, Michael Lanzer and Thomas Jänisch
Reference: 
Tropical Medicine & International Health Volume 19, Issue 6, pages 690–697, June 2014

The increase in molecular markers linked with SP resistance jeopardises the efficacy of IPTp and the planned IPTi interventions in Burkina Faso, calling for careful monitoring of genotypic resistance markers and in vivo validation of IPT efficacy.

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Malaria Risk Factors in Women on Intermittent Preventive Treatment at Delivery and Their Effects on Pregnancy Outcome in Sanaga-Maritime, Cameroon

June 25, 2013 - 09:57 -- Open Access
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Author(s): 
Calvin Tonga, Helen Kuokuo Kimbi, Judith Kuoh Anchang-Kimbi, Hervé Nyabeyeu Nyabeyeu, Zacharie Bissemou Bissemou, Léopold G. Lehman
Reference: 
PLoS ONE 8(6): e65876
MalariaWorld

Malaria is known to have a negative impact on pregnant women and their foetuses

Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal

April 25, 2013 - 07:06 -- Open Access
Author(s): 
Lo AC, Faye B, Gaye O, et al.
Reference: 
Malaria Journal 2013, 12:137 (23 April 2013)
MalariaWorld

The sensitivity of P. falciparum to SMC drugs should be regularly monitored in areas deploying this intervention.

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