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artemether-lumefantrine

Open Access | Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study

March 21, 2011 - 07:17 -- Patrick Sampao
Author(s): 
Billy E Ngasala ., Maja Malmberg., Andreas Martensson ., et al.
Reference: 
Malaria Journal 2011, 10:64

The aim of this study was to assess the effectiveness of artemether-lumefantrine (AL), presently the most favoured ACT in Africa, in under-five children with uncomplicated Plasmodium falciparum malaria in Tanzania, when provided by community health workers (CHWs) and administered unsupervised by parents or guardians at home.

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Open Access | Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children

March 2, 2011 - 09:05 -- Kabogo Ndegwa
Author(s): 
Nambozi M, Van Geertruyden J, Hachizovu S, Chaponda M, Mukwamataba D, Mulenga M, Ubben D, D'Alessandro U
Reference: 
Malaria Journal 2011, 10:50 (28 February 2011)

DHA/PQP was as efficacious, safe and well tolerated in treatment of uncomplicated malaria as AL, though in the latter group more new infections during the follow up were observed.

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Open Access | A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia

January 12, 2011 - 10:04 -- Kabogo Ndegwa
Author(s): 
Sesay S, Milligan P, Touray E, Sowe M, Webb EL, Greenwood BM, Bojang KA
Reference: 
Malaria Journal 2011, 10:2 (7 January 2011)

Due to the very low incidence of malaria, no firm conclusion can be drawn on the added benefit of IPTc in preventing clinical episodes of malaria among children who had access to HMM in The Gambia.

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Confirmed Vivax Resistance to Chloroquine and Effectiveness of Artemether-Lumefantrine for the Treatment of Vivax Malaria in Ethiopia

January 10, 2011 - 07:55 -- Patrick Sampao
Author(s): 
Ambachew M. Yohannes, Awash Teklehaimanot, Yngve Bergqvist and Pascal Ringwald
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 137 - 140.

Chloroquine (CQ) is still the drug of choice for the treatment of vivax malaria in Ethiopia, whereas artemether-lumefantrine (AL) is for falciparum malaria. In this setting, clinical malaria cases are treated with AL.

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The effects of introducing artemether-lumefantrine malaria treatment and insecticide-impregnated bed nets to an elective surgical hospital

December 20, 2010 - 12:26 -- Kabogo Ndegwa
Author(s): 
S Abram, W J Harrison, J Cashman, and C B D Lavy
Reference: 
Tropical Doctor, Volume 41, Number 1, Pp. 15-17

Malaria and anaemia in patients admitted for elective orthopaedic operations commonly cause delays to surgery.

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Open Access | SMS for Life: a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technology

November 2, 2010 - 06:32 -- Kabogo Ndegwa
Author(s): 
Barrington J, Wereko-Brobby O, Ward P, Mwafongo W, Kungulwe S
Reference: 
Malaria Journal 2010, 9:298 (27 October 2010)

The SMS for Life pilot provided visibility of anti-malarial stock levels to support more efficient stock management using simple and widely available SMS technology, via a public-private partnership model that worked highly effectively.

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Open Access | Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine

October 15, 2010 - 07:44 -- Kabogo Ndegwa
Author(s): 
Ali S, Najmi MH, Tarning J, Lindegardh N
Reference: 
Malaria Journal 2010, 9:275 (11 October 2010)

The overall pharmacokinetic properties of artemether and dihydroartemisinin in healthy Pakistani subjects are comparable to healthy subjects and patients from other populations.

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Brief Report: Increased Risk of Early Vomiting among Infants and Young Children Treated with Dihydroartemisinin-Piperaquine Compared with Artemether-Lumefantrine for Uncomplicated Malaria

October 4, 2010 - 12:25 -- Patrick Sampao
Author(s): 
Darren Creek, Victor Bigira, Emmanuel Arinaitwe, Humphrey Wanzira, Abel Kakuru, Jordan Tappero, Moses R. Kamya, Grant Dorsey, AND Taylor G. Sandison
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 873 - 875.

We used data from a randomized control trial in rural Uganda to compare the risk of early vomiting (within one hour of dosing) for children 6–24 months of age randomized to receive DP (n = 240) or AL (n = 228) for treatment of uncomplicated malaria.

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Open Access | Knowledge, Attitudes, and Practices about Malaria and Its Control in Rural Northwest Tanzania

September 30, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
Humphrey D. Mazigo, Emmanuel Obasy, Wilhellmus Mauka, Paulina Manyiri, Maria Zinga, Eliningaya J. Kweka, Ladslaus L. Mnyone, Jorg Heukelbach
Reference: 
Malaria Research and Treatment, Volume 2010 (2010)

Despite reasonable knowledge on malaria and its preventive measures, there is a need to improve availability of information through proper community channels. Special attention should be given to illiterate community members. High acceptance of indoor residual spraying and high level of bed net ownership should be taken as an advantage to improve malaria control.

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Open Access | Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in Kenya

September 23, 2010 - 08:49 -- Kabogo Ndegwa
Author(s): 
Wasunna B, Zurovac D, Bruce J, Jones C, Webster J, Snow RW
Reference: 
Malaria Journal 2010, 9:261 (18 September 2010)

In-service training and provision of job aids alone may not be adequate to improve the prescribing, dispensing and counseling tasks necessary to change malaria case-management practices and the inclusion of supervision and post-training follow-up should be considered in future clinical practice change initiatives.

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