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artemether-lumefantrine

Open Access | Effect of Supplementation with Zinc and Other Micronutrients on Malaria in Tanzanian Children: A Randomised Trial

November 30, 2011 - 07:10 -- Kabogo Ndegwa
Author(s): 
Jacobien Veenemans, Paul Milligan, Hans Verhoef, et al.
Reference: 
PLoS Med 8(11): e1001125

MalariaWorldWe found no evidence from this trial that zinc supplementation protected against malaria.

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Open Access | Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis

November 3, 2011 - 09:37 -- Patrick Sampao
Author(s): 
Michael Makanga, Quique Bassat, Philip J. Rosenthal, et al.
Reference: 
Am J Trop Med Hyg 2011 85:793-804

MalariaWorldThis study is the largest data set to date assessing AL therapy for treatment of acute uncomplicated P. falciparum malaria.

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Increased pfmdr1 Copy Number and Sequence Polymorphisms in Plasmodium falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-Lumefantrine

October 17, 2011 - 09:47 -- Kabogo Ndegwa
Author(s): 
Nahla B. Gadalla, Ishag Adam, Salah-Eldin Elzaki, Sahar Bashir, Izdihar Mukhtar, Mary Oguike, Amal Gadalla, Fathi Mansour, David Warhurst, Badria B. El-Sayed, and Colin J. Sutherland
Reference: 
Antimicrobial Agents and Chemotherapy, November 2011,p. 5408-5411, Vol. 55, No. 11

MalariaWorldMolecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed.

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Adherence to Treatment With Artemether-Lumefantrine for Uncomplicated Malaria in Rural Malawi

September 27, 2011 - 07:36 -- Patrick Sampao
Author(s): 
Kimberly E. Mace, Dyson Mwandama, James Jafali, Madalitso Luka, Scott J. Filler, John Sande, Doreen Ali, S. Patrick Kachur, Don P. Mathanga and Jacek Skarbinski
Reference: 
Clinical Infectious Diseases, Volume53, Issue 8 Pp. 772-779.

We conducted both pill counts and in-home interviews on medication consumption 72 hours after patients received AL. Complete adherence was defined as correctly taking all 6 AL doses, as assessed by pill count and dose recall. We used logistic regression to identify factors associated with complete adherence.

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Prolonged Selection of pfmdr1 Polymorphisms After Treatment of Falciparum Malaria With Artemether-Lumefantrine in Uganda

September 2, 2011 - 13:14 -- Patrick Sampao
Author(s): 
Frederick N. Baliraine and Philip J. Rosenthal
Reference: 
J Infect Dis. (2011) 204 (7): 1120-1124.

We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite isolates and parasites that emerged after treatment of uncomplicated malaria in a longitudinal cohort of Ugandan children.

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Pharmacokinetic and Pharmacodynamic Characteristics of a New Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium falciparum Malaria

August 18, 2011 - 11:41 -- Kabogo Ndegwa
Author(s): 
Abdoulaye A. Djimdé, Mamadou Tekete, Salim Abdulla, John Lyimo, Quique Bassat, Inacio Mandomando, Gilbert Lefèvre, Steffen Borrmann, and for the B2303 Study Group
Reference: 
Antimicrobial Agents and Chemotherapy, September 2011,p. 3994-3999, Vol. 55, No. 9

The pharmacokinetic and pharmacodynamic properties of a new pediatric formulation of artemether-lumefantrine, dispersible tablet, were determined within the context of a multicenter, randomized, parallel-group study.

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Open Access | Patterns of anti-malarial drug treatment among pregnant women in Uganda

June 7, 2011 - 07:44 -- Kabogo Ndegwa
Author(s): 
Sangare LR, Weiss NS, Brentlinger PE, Richardson BA, Staedke SG, Kiwuwa MS, Stergachis A
Reference: 
Malaria Journal 2011, 10:152 (6 June 2011)

Self-reported malaria was extremely common in this population and adherence to treatment guidelines for the management of malaria in pregnancy was poor.

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Open Access | Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study

May 5, 2011 - 07:01 -- Kabogo Ndegwa
Author(s): 
Valerie D'Acremont, Judith Kahama-Maro, Ndeniria Swai, Deo Mtasiwa, Blaise Genton, Christian Lengeler
Reference: 
Malaria Journal 2011, 10:107 (29 April 2011)

Programmatic implementation of mRDTs in a moderately endemic area reduced drastically over-treatment with anti-malarials.

Therapeutic Efficacy and Effects of Artemether-Lumefantrine and Artesunate-Amodiaquine Coformulated or Copackaged on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum Malaria in Southwest Nigeria

May 4, 2011 - 15:07 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Akintunde Sowunmi, Titilope M. Okuboyejo, Christian T. Happi, Onikepe A. Folarin, Obaro S. Michael, AND Elsie O. Adewoye
Reference: 
Am J Trop Med Hyg, May 2011; 84: 813 - 819.

The therapeutic efficacy and effects of artemether-lumefantrine (AL) and artesunate-amodiaquine co-formulated (AAcf) or co-packaged (AAcp) on malaria-associated anemia (MAA) were evaluated in 285 children < 12 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive one of the three drug combinations.

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Novartis Malaria Initiative: best practice example of pharmaceutical industry's engagement in the fight against malaria

March 29, 2011 - 07:35 -- Kabogo Ndegwa
Author(s): 
Gilbert Lefèvre, Anne Claire Marrast, Heiner Grueninger
Reference: 
Annals of the New York Academy of Sciences Volume 1222, Pharmaceutical Science to Improve the Human Condition: Prix Galien 2010 pages 19–29, March 2011

Despite considerable advances in the treatment and prevention of malaria, Plasmodium falciparum is still a threat to millions of people across the world, particularly in sub-Saharan Africa, with infants and young children bearing the greatest burden in terms of morbidity and mortality.

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