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antigens

Open Access | From the Cover: Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

January 25, 2012 - 06:53 -- Kabogo Ndegwa
Author(s): 
James J. Moon, Heikyung Suh, Adrienne V. Li, Christian F. Ockenhouse, Anjali Yadava, and Darrell J. Irvine
Reference: 
PNAS January 24, 2012 vol. 109 no. 4 1080-1085

MalariaWorldFor subunit vaccines, adjuvants play a key role in shaping immunological memory.

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Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens.

December 9, 2011 - 08:26 -- Patrick Sampao
Author(s): 
Lee GC, Jeon ES, Le DT, Kim TS, Yoo JH, Kim HY, Chong CK.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):989-993.

MalariaWorldOur results showed that its sensitivities for P. falciparum, P. vivax, and mixed-species infection were 96.5%, 95.3%, and 85.7%, respectively. In addition, its specificity was high (99.4%).

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Open Access | Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HTTM and Montanide ISA 51 in rhesus macaques

July 6, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Kusi KA, Remarque EJ, Riasat V, Walraven V, Thomas AW, Faber BW, Kocken CH
Reference: 
Malaria Journal 2011, 10:182 (4 July 2011)

The study highlights the safety and immunological benefits of DiCo mix as a potential human vaccine against blood stage malaria, especially when formulated in CoVaccine HTTM, and adds to the accumulating data on the specificity broadening effects of DiCo mix.

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Human Cord Blood CD4+CD25hi Regulatory T Cells Suppress Prenatally Acquired T Cell Responses to Plasmodium falciparum Antigens

February 16, 2011 - 07:36 -- Kabogo Ndegwa
Author(s): 
Maria S. Mackroth, Indu Malhotra, Peter Mungai, Davy Koech, Eric Muchiri, and Christopher L. King
Reference: 
The Journal of Immunology March 1, 2011 vol. 186 no. 5 2780-2791

n malaria endemic regions, a fetus is often exposed in utero to Plasmodium falciparum blood-stage Ags.

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Malaria Vaccine Design: Immunological Considerations

November 2, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Michael F. Good, Denise L. Doolan
Reference: 
Immunity, Volume 33, Issue 4, 29 October 2010, Pages 555-566

The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one.

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Open Access | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens

September 16, 2010 - 14:14 -- Kabogo Ndegwa
Author(s): 
Tamsir O. Diallo, Franck Remoue,Gilles Riveau,. et al
Reference: 
PLoS ONE 5(9): e12764

Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent.

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Open Access | Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1

August 11, 2010 - 13:03 -- Kabogo Ndegwa
Author(s): 
Pandey JP, Morais CG, Fontes CJ, Braga EM
Reference: 
Malaria Journal 2010, 9:229 (9 August 2010)

Results presented here show that immunoglobulin GM allotypes contribute to the natural antibody responses to P. vivax malaria antigens. These findings have important implications for the effectiveness of vaccines containing PvAMA-1 or PvMSP1-19 antigens.

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