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artemether-lumefantrine

Artemether-lumefantrine and liver enzyme abnormalities in non-severe Plasmodium falciparum malaria in returned travellers: a retrospective comparative study with quinine-doxycycline in a Portuguese centre

February 6, 2017 - 15:43 -- Open Access
Author(s): 
André Silva-Pinto, Rogério Ruas, Francisco Almeida, Raquel Duro, André Silva, Cândida Abreu and António Sarmento
Reference: 
Malaria Journal 2017 16:43, 25 January 2017

Treatment of uncomplicated falciparum malaria with artemisinin-based therapy might cause asymptomatic liver enzyme abnormalities in the first days of treatment.

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High efficacy of artemether-lumefantrine and declining efficacy of artesunate + sulfadoxine-pyrimethamine against Plasmodium falciparum in Sudan (2010–2015): evidence from in vivo and molecular marker studies

May 24, 2016 - 16:28 -- Open Access
Tags: 
Author(s): 
Ahmed A. Adeel, Fahad Awad Ali Elnour, Rania A. Nada, et al.
Reference: 
Malaria Journal 2016 15:285, 21 May 2016

The findings of this study call for a need to review the Sudan malaria treatment policy.

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Quality and stability of artemether-lumefantrine stored under ambient conditions in rural Mali

December 15, 2014 - 12:36 -- Open Access
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Author(s): 
John Gitua, Aaron Beck, John Rovers
Reference: 
Malaria Journal 2014, 13:474 (4 December 2014)

The IPCA products contained the same drugs in the same amount as on their package label and were identical to the reference product.

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The challenge to avoid anti-malarial medicine stock-outs in an era of funding partners: the case of Tanzania

May 22, 2014 - 08:54 -- Open Access
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Author(s): 
Mikkelsen-Lopez I, Shango W, Barrington J, Ziegler R, Smith T, de Savigny D
Reference: 
Malaria Journal 2014, 13 :181 (11 May 2014)

The reduced ACT availability and irregular pattern of supply were due to cumbersome bureaucratic processes and delays both within the country and the main donor, the Global Fund to Fight AIDS, Tuberculosis and Malaria.

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Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana

October 23, 2012 - 17:28 -- Patrick Sampao
Author(s): 
Eibach D, Ceron N, Krishnalall K, Carter K, Bonnot G, Bienvenu A, Picot S
Reference: 
Malaria Journal 2012, 11:347 (19 October 2012)

MalariaWorldA therapeutic efficacy study was conducted using artemetherlumefantrine + primaquine against P. vivax to evaluate a treatment alternative for chloroquine.

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Surveillance of the efficacy of artemetherlumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009

October 9, 2012 - 13:34 -- Kabogo Ndegwa
Author(s): 
Dorkenoo MA, Barrette A, Agbo YM, Bogreau H, Kutoati S, Sodahlon YK, Morgah K
Reference: 
Malaria Journal 2012, 11:338 (8 October 2012)

MalariaWorldBoth formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies.

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NOT Open Access | Participatory healthcare-provider orientation to improve artemether-lumefantrine-based drug treatment of uncomplicated malaria: a cluster quasi-experimental study

August 29, 2012 - 15:15 -- Patrick Sampao
Author(s): 
Norbert G Anyama, James K Tibenderana, Paul Kutyabami, Pakoyo F Kamba, Freddy E Kitutu, Richard O Adome
Reference: 
BMJ Qual Saf , Volume 21, Issue 9 2012;21:768-777

MalariaWorldA cluster quasi-experimental study. The authors developed strategies to address challenges encountered by healthcare providers during clinical management of malaria. The primary outcome was patient knowledge on prescribed malaria drug treatment.

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Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an individual-patient analysis of eight randomized controlled trials in sub-Saharan Africa

August 7, 2012 - 11:48 -- Kabogo Ndegwa
Author(s): 
Zwang J, Dorsey G, Djimdé A, Karema C, Mårtensson A, Ndiaye J, Sirima SB, Olliaro P
Reference: 
Malaria Journal 2012, 11:260 (2 August 2012)

MalariaWorldASAQ was comparatively well-tolerated. Safety information is important, and must be collected and analysed in a standardized way.

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Pharmacovigilance of artemether-lumefantrine in pregnant women followed until delivery in Rwanda

July 13, 2012 - 10:21 -- Patrick Sampao
Author(s): 
Rulisa S, Kaligirwa N, Agaba S, Karema C, Mens PF, De Vries PJ
Reference: 
Malaria Journal 2012, 11:225 (6 July 2012)

MalariaWorldIn this pharmacovigilance study, the exposed group (pregnant women with malaria given artemether-lumefantrine), and a matched non-exposed group (pregnant women without malaria and no exposure to artemether-lumefantrine) were followed until delivery.

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Repeated Artemisinin-Based Combination Therapies in a Malaria Hyperendemic Area of Mali: Efficacy, Safety, and Public Health Impact

July 4, 2012 - 12:36 -- Patrick Sampao
Author(s): 
Issaka Sagara, Bakary Fofana, Abdoulaye A. Djimde, et al.
Reference: 
Am J Trop Med Hyg 2012 87:50-56

MalariaWorldWe conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007.

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