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CD8 T Cell

Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

August 2, 2010 - 13:26 -- Patrick Sampao
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
PLoS Pathog 6(7): e1000998

Here, we used surrogate T cell activation markers to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses. Our data show that the differential susceptibility of RAS-immune inbred mouse strains to Plasmodium berghei or P. yoelii sporozoite challenge does not result from host- or parasite-specific decreases in the CD8 T cell response.

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