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red blood cells

Open Access | Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India

July 12, 2011 - 14:16 -- Patrick Sampao
Author(s): 
R.C. Mahajan, K. Narain & J. Mahanta
Reference: 
Indian J Med Res 133, June 2011, pp 662-664

Flowcytometry was used to study expression of CR1, CD55 and CD59 in 50 Pf cases and 30 normal healthy volunteers.

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Open Access | Oral Presentation: A micro-bead device to explore Plasmodium falciparum-infected, spherocytic or aged red blood cells prone to mechanical retention by spleen endothelial slits

November 5, 2010 - 12:55 -- Patrick Sampao
Author(s): 
Guillaume Deplaine, Innocent Safeukui,Pierre A Buffet et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):O10 (20 October 2010)

We designed a micro-bead device mimicking the geometry of the human narrow and short inter-endothelial slits. Upon filtration through a mixture of 5-25 μm diameter micro-beads, Plasmodium falciparum-hosting RBC (Pf-RBC) were retained in a parasite developmental stage-dependent way, the retention rates of a subset of ring-RBC being similar in micro-beads and in isolated-perfused human spleens.

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Conserved regions of the Plasmodium falciparum rhoptry-associated protein 3 mediate specific host-pathogen interactions during invasion of red blood cells

November 2, 2010 - 14:38 -- Patrick Sampao
Author(s): 
Jeison García, Hernando Curtidor, Magnolia Vanegas, Gabriela Arévalo-Pinzon, Manuel A. Patarroyo, Manuel E. Patarroyo
Reference: 
Peptides, Volume 31, Issue 12, December 2010, Pages 2165-2172

In this study, the sequence of RAP-3 was finely mapped using synthetic peptides in order to identify which are the specific binding regions involved in RAP3–RBC interactions.

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Conserved high activity binding peptides from the Plasmodium falciparum Pf34 rhoptry protein inhibit merozoites in vitro invasion of red blood cells

October 11, 2010 - 14:16 -- Patrick Sampao
Author(s): 
Gabriela Arévalo-Pinzón, Hernando Curtidor, Magnolia Vanegas, Carolina Vizcaíno, Manuel A. Patarroyo, Manuel E. Patarroyo
Reference: 
Peptides, Volume 31, Issue 11, November 2010, Pages 1987-1994

Receptor–ligand assays carried out in this study found that peptides 36,051 (101DKKFSESLKAHMDHLKILNN120Y), 36,053 (141KKYIIKEIQNNKYLNKEKKS160), 36,055 (181WLESVNNIEEKSNILKNIKS200Y) and 36,056 (201QLLNNIASLNHTLSEEIKNI220Y), located in the central portion of Pf34, were found to establish protease-sensitive interactions of high affinity and specificity with receptors on the surface of red blood cell (RBCs).

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Host Response and Inflammation: Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

August 18, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Fernanda G. Baptista, Ana Pamplona, Ana C. Pena, Maria M. Mota, Sylviane Pied, and Ana M. Vigário
Reference: 
Infect. Immun., Sep 2010; 78: 4033 - 4039.

Importantly, these results also demonstrated that the experimental cerebral malaria model shares many features with human pathology and might be a relevant model to study its pathogenesis.

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Biophotonic techniques for the study of malaria-infected red blood cells

August 2, 2010 - 08:01 -- Patrick Sampao
Author(s): 
Jakob M., Alessandro E., et al.
Reference: 
Medical and Biological Engineering and Computing

In this article, we review a wide range of optical techniques for quantitative measurements of critical homeostatic parameters in malaria-infected red blood cells.

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