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β-Hematin

Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin

November 13, 2009 - 11:05 -- Ingeborg van Schayk
Author(s): 
Lucie Guetzoyan, Xiao-Min Yu, Florence Ramiandrasoa, Stéphanie Pethe, Christophe Rogier, Bruno Pradines, Thierry Cresteil, Martine Perrée-Fauvet, Jean-Pierre Mahy
Reference: 
Bioorganic & Medicinal Chemistry , Volume 17, Issue 23, 1 December 2009, Pages 8032-8039

A series of acridine derivatives were synthesised and their in vitro antimalarial activity was evaluated against one chloroquine-susceptible strain (3D7) and three chloroquine-resistant strains (W2, Bre1 and FCR3) of Plasmodium falciparum.

Medical Condition: 
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