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antimalarial

Desbutyl-Lumefantrine Is a Metabolite of Lumefantrine with Potent In Vitro Antimalarial Activity That May Influence Artemether-Lumefantrine Treatment Outcome

March 1, 2011 - 06:25 -- Kabogo Ndegwa
Author(s): 
Rina P. M. Wong, Sam Salman, Kenneth F. Ilett, Peter M. Siba, Ivo Mueller, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 1194-1198, Vol. 55, No. 3

Desbutyl-lumefantrine (DBL) is a metabolite of lumefantrine. Preliminary data from Plasmodium falciparum field isolates show greater antimalarial potency than, and synergy with, the parent compound and synergy with artemisinin.

In vivo antimalarial activity of ginseng extracts

February 22, 2011 - 08:07 -- Kabogo Ndegwa
Author(s): 
Han Han, Yan Chen, Hongtao Bi, Li Yu, Chengxin Sun, Shanshan Li, Sylla Alpha Oumar, Yifa Zhou
Reference: 
Pharmaceutical Biology March 2011, Vol. 49, No. 3 Pages 283-289

Protopanaxadiol-type ginsenosides have remarkably suppressive activity during early infection, while acidic ginseng polysaccharides have significant prophylactic activity against malaria by stimulating the immune system.

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Review: Pitfalls in new artemisinin-containing antimalarial drug development

February 4, 2011 - 07:43 -- Patrick Sampao
Author(s): 
Ronan Jambou, Jacques Le Bras, Milijaona Randrianarivelojosia
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 82-90

Alongside the deployment of multifocal control programs, the process ranging from artemisia crop production to accreditation of new ACT combinations urgently needs to be strengthened to supply sufficient quantities of high-quality drugs.

Review: Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

February 2, 2011 - 13:53 -- Patrick Sampao
Author(s): 
Xavier C. Ding, Hans-Peter Beck, Giovanna Raso
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 73-81

In this review different models of artemisinins’ molecular action are briefly presented, focusing on recent advances, and the evidence of potential association between various gene polymorphisms and artemisinin resistance is comprehensively reviewed.

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Opinion: How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance

February 2, 2011 - 13:23 -- Patrick Sampao
Author(s): 
Ian Hastings
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 67-72

Recent reports suggest that early stages of resistance to artemisinins and/or its partner drugs could be occurring, thus it is timely to briefly review exactly how ACTs slow the origin and spread of resistance and to interpret the threat of resistance within this context.

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Short Communication: Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether

January 21, 2011 - 08:42 -- Patrick Sampao
Author(s): 
Ramesh Chandra, L.M. Tripathi, J.K. Saxena, S.K. Puri
Reference: 
Parasitology International, Volume 60, Issue 1, January 2011, Pages 97-100

In this study, we examined the relationship between the intracellular levels of glutathione (GSH) and antioxidant enzymes and resistance to the artemisinin-based drug arteether in experimentally selected arteether-resistant Plasmodium vinckei.

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Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

January 14, 2011 - 13:07 -- Patrick Sampao
Author(s): 
Subash Chandra Mohapatra., Hemandra Kumar Tiwari.,Shyam Singh Chauhan., et al.
Reference: 
Journal of Biological Inorganic Chemistry, Volume 15, Number 3, 373-385

Our results suggest that these two compounds have antimalarial activities, and the IC50 values (0.025–0.032 μg/ml) are similar to the IC50 value of the standard drug chloroquine used in the bioassay. Lineweaver–Burk plots for inhibition of plasmepsin II by LCu(CH3COO)2 and LCuCl2 show that the inhibition is competitive with respect to the substrate.

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In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

January 5, 2011 - 07:33 -- Kabogo Ndegwa
Author(s): 
Asokan Bagavan, Abdul Abdul Rahuman, Naveen Kumar Kaushik & Dinkar Sahal
Reference: 
Parasitology Research, Vol. 108, Issue 1, Pages 15-22

Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds.

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Open Access | Cost-Effectiveness of Pre-Referral Antimalarial, Antibacterial, and Combined Rectal Formulations for Severe Febrile Illness

January 4, 2011 - 08:26 -- Kabogo Ndegwa
Author(s): 
James Buchanan, Borislava Mihaylova, Alastair Gray, Nicholas White
Reference: 
PLoS ONE 5(12): e14446

Antimalarial, antibacterial and combined rectal formulations are likely to be cost-effective interventions for severe febrile illness in the community.

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Review: Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space

December 22, 2010 - 09:32 -- Patrick Sampao
Author(s): 
Naman K Shah, Gajender PS Dhillon, Adtiya P Dash, Usha Arora, Steven R Meshnick, Neena Valecha
Reference: 
The Lancet Infectious Diseases, Volume 11, Issue 1, January 2011, Pages 57-64

We did a systematic review of P falciparum malaria drug-efficacy studies in India to summarise drug-resistance data and describe changes over the past 30 years to inform future policy.

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