Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells.
The synthesis of a novel series of thiolactone–isatin hybrids led to the discovery of tetracyclic by-products which displayed superior antiplasmodial activity.
A series of N′-substituted-2-(5-nitrofuran or 5-nitrothiophen-2-yl)-3H-benzo[d]imidazole-5-carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent Plasmodium berghei.
This is the first report of a heterologous co-expression system in which a plasmodial chaperone is harnessed for the improved production and purification of a plasmodial target protein.
The present study aimed to document the indigenous medicinal plant utilization for the management of malaria and related symptoms in Togo Maritime Region.
This study identified plants with low IC50 values, high percent chemo suppression and low cytotoxicity thus potential sources for novel antiplasmodial agents.
Flavin adenine dinucleotide (FAD) is reduced by NADPH–E. coli flavin reductase (Fre) to FADH2 in aqueous buffer at pH 7.4 under argon.
From unstressed, stressed and accelerated stability samples of lumefantrine API and FPPs, nine compounds were detected and characterized to be lumefantrine related impurities.
A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235) strains of Plasmodium falciparum.
Histone acetylation plays an important role in regulating gene transcription and silencing in Plasmodium falciparum.