The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10240 malaria professionals are enjoying the free benefits of MalariaWorld today

antimalarial

Antimalarial Drug Sensitivity Profile of Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I in vitro Assay and Molecular Analysis

July 8, 2011 - 09:02 -- Patrick Sampao
Author(s): 
Hoseah M. Akala., Fredrick L. Eyase., Douglas S. Walsh., et al
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 1 34-41

In 2007–2008, we assayed 121 P. falciparum field isolates from western Kenya for 50% inhibitory concentrations (IC50) against 6 antimalarial drugs using a SYBR Green I in vitro assay: 91 immediate ex vivo (IEV) and 30 culture-adapted, along with P. falciparum reference clones D6 (chloroquine [CQ] sensitive) and W2 (CQ resistant).

Country: 
Medical Condition: 
Medical Treatment: 

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

June 27, 2011 - 12:43 -- Patrick Sampao
Author(s): 
Akira Sato, Akiko Hiramoto, Hye-Sook Kim, et al.
Reference: 
Parasitology International, Volume 60, Issue 3, September 2011, Pages 270-273

Here, we report the in vitro and in vivo antimalarial activities of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against P. falciparum and Plasmodium berghei parasites.

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

June 18, 2011 - 15:05 -- Kabogo Ndegwa
Author(s): 
Noah S. Butler, Nathan W. Schmidt, Ashley M. Vaughan, Ahmed S. Aly, Stefan H.I. Kappe, John T. Harty
Reference: 
Cell Host & Microbe, Volume 9, Issue 6, 16 June 2011, Pages 451-462

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated sporozoites (RAS) remain the “gold standard” for sterilizing protection against Plasmodium infection in human vaccinees.

Medical Condition: 
Medical Treatment: 

Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates

May 25, 2011 - 07:24 -- Kabogo Ndegwa
Author(s): 
Nitin Kumar, Shabana I. Khan, Himanshu Atheaya, Ritu Mamgain, Diwan S. Rawat
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 7, July 2011, Pages 2816-2827

A series of tetraoxanes, tetraoxane-amine and tetraoxane-amide conjugates have been synthesized and screened for in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.

Medical Treatment: 

Antimalarial Effects of Human Immunodeficiency Virus Protease Inhibitors in Rhesus Macaques

May 24, 2011 - 07:53 -- Kabogo Ndegwa
Author(s): 
Youjia Li, Li Qin, Nanzheng Peng, Guangjie Liu, Siting Zhao, Zhengxiang He, and Xiaoping Chen
Reference: 
Antimicrobial Agents and Chemotherapy, June 2011,p. 3039-3042, Vol. 55, No. 6

The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time.

Medical Condition: 
Medical Treatment: 

Antiplasmodial activity of botanical extracts against Plasmodium falciparum

April 20, 2011 - 07:49 -- Kabogo Ndegwa
Author(s): 
Asokan Bagavan, Abdul Abdul Rahuman, Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan & Dinkar Sahal
Reference: 
Parasitology Research, Volume 108, Number 5, 1099-1109

The absence of a vaccine and the rampant resistance to almost all antimalarial drugs have accentuated the urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy.

Medical Treatment: 

A novel antimalarial treatment based on engineered antibodies

April 6, 2011 - 16:06 -- Horacio Bach

The treatment of malaria has been hampered by the appearance of parasites resistant to conventional malaria drugs. Disease progression relies on the adherence of parasite-containing red blood cells to the blood vessel tissues. This condition allows the parasite to evade its clearance from the blood. Current treatments focus on killing the parasites inside of infected red blood cells but resistant strains have evolved with the ability to pump the drugs out of the erythrocytes.

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT

March 28, 2011 - 12:33 -- Kabogo Ndegwa
Author(s): 
Vincent K. Zishiri, Roger Hunter, Peter J. Smith, Dale Taylor, Robert Summers, Kiaran Kirk, Rowena E. Martin, Timothy J. Egan
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 5, May 2011, Pages 1729-1742

A series of 12 new dibemethin (N-benzyl-N-methyl-1-phenylmethanamine) derivatives bearing an N-aminomethyl group attached to the one phenyl ring and an H, Cl, OCH3 or N(CH3)2 group on the other have been synthesized.

Medical Condition: 
Medical Treatment: 

In vitro antimalarial activity of ICL670: A further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin

March 28, 2011 - 11:58 -- Kabogo Ndegwa
Author(s): 
P. Sonnet, C. Mullié
Reference: 
Experimental Parasitology, Volume 128, Issue 1, May 2011, Pages 26-31

Iron chelators such as deferiprone, deferoxamine (DFO) and ICL670 (deferasirox) have previously been shown to display in vitro and/or in vivo antimalarial activities.

Medical Treatment: 

Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast

March 22, 2011 - 11:38 -- Kabogo Ndegwa
Author(s): 
Makoah N. Aminake, Sebastian Schoof, Ludmilla Sologub, Monika Leubner, Marc Kirschner, Hans-Dieter Arndt, and Gabriele Pradel
Reference: 
Antimicrobial Agents and Chemotherapy, April 2011, p. 1338-1348, Vol. 55, No. 4

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the malaria parasite, an organelle of prokaryote origin having essential metabolic functions.

Medical Condition: 
Medical Treatment: 

Pages

Subscribe to RSS - antimalarial