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antimalarial

Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

February 22, 2012 - 14:40 -- Patrick Sampao
Author(s): 
M. Zhang, Veronica; Chavchich, Marina; C. Waters, Norman
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 456-472(17)

MalariaWorldIn this review, progress on selected protein kinases is described. As the search for novel antimalarials continues, an understanding of the phosphor-regulatory pathways will not only validate protein kinase targets, but also will identify novel chemotypes to thwart malaria drug resistance.

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Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria

February 22, 2012 - 14:27 -- Patrick Sampao
Author(s): 
H. Peyton, David
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 400-407(8)

MalariaWorldThis short review tells the story of how Reversed Chloroquine drugs (RCQs) were developed.

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The Medicinal Chemistry of Novel Approaches for the Treatment of Malaria

February 22, 2012 - 14:16 -- Patrick Sampao
Author(s): 
J. Meyers, Marvin
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 371-372(2)

MalariaWorldThe introduction of artemisinin and artemisinin combination therapies (ACTs) in 2005 has begun to reverse the trend. While this is a good sign, there have been reports of resistance to artemisinin in Southeast Asia [2].

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Short Report: Different Patterns of pfcrt and pfmdr1 Polymorphisms in P. falciparum Isolates from Nigeria and Brazil: The Potential Role of Antimalarial Drug Selection Pressure

February 3, 2012 - 14:08 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, et al.
Reference: 
Am J Trop Med Hyg 2012 86:211-213

MalariaWorldWe provide first evidence of emergence of the CVMNT haplotype in West Africa. The high prevalence of pfcrt CVIET and SVMNT haplotypes in Nigeria and Brazil, respectively, is indicative of different selective pressure by chloroquine and amodiaquine.

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In vitro antibacterial and antimalarial activity of dehydrophenylalanine-containing undecapeptides alone and in combination with drugs

January 23, 2012 - 09:49 -- Patrick Sampao
Author(s): 
Sarika Pathak Sharmaa, Jyotsna Sharmaa, Shamsher Singh Kanwarb, Virander Singh Chauhan
Reference: 
International Journal of Antimicrobial Agents, Volume 39, Issue 2, February 2012, Pages 146–152

MalariaWorldThese results provide insight into basic design principles for generating new clinically relevant lead peptides. It also provides an alternative strategy where a peptide and a non-peptide drug can be used in combination to battle increasingly drug-resistant microbes.

Open Access | High content live cell imaging for the discovery of new antimalarial marine natural products

January 5, 2012 - 12:32 -- Patrick Sampao
Author(s): 
Cervantes S, Stout EP, Prudhomme J, Engel S, Bruton M, Cervantes M, Carter D, Tae-Chang Y, Hay ME, Aalbersberg W, Kubanek J, Le Roch KG
Reference: 
BMC Infectious Diseases 2012, 12:1 (3 January 2012)

MalariaWorldCollectively, our results show that high-content live cell-imaging (HCLCI) can be used to screen chemical libraries and identify parasite specific inhibitors with limited host cytotoxic effects.

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Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

December 14, 2011 - 13:28 -- Patrick Sampao
Author(s): 
Akalu Mesfin, Mirutse Giday, Abebe Animut, Tilahun Teklehaymanot
Reference: 
Journal of Ethnopharmacology, Volume 139, Issue 1, 6 January 2012, Pages 221-227

MalariaWorldResults of this study can be used as a basis for further phytochemical and pharmacological investigations in the effort for search of new and locally affordable antimalarial agents.

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Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives

November 25, 2011 - 14:57 -- Patrick Sampao
Author(s): 
Akira Sato, Satoru Kawai, Hye-Sook Kim, et al.
Reference: 
Parasitology International, Volume 60, Issue 4, December 2011, Pages 488-492

MalariaWorldWe previously reported the in vitro and in vivo antimalarial potencies of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) and 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Plasmodium falciparum and Plasmodium berghei parasites.

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Chemical constituents and biological activities of Iranian Artemisia species

November 22, 2011 - 13:55 -- Patrick Sampao
Author(s): 
Abdolhossein Rustaiyan, Shiva Masoudi
Reference: 
Phytochemistry Letters, Volume 4, Issue 4, December 2011, Pages 440-447

MalariaWorldAcyclic monoterpenes, monoterpene hydroperoxide, bicyclic monoterpene glycosides and unusual monoterpenes have been found in some Iranian Artemisia species.

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Open Access | Accessibility, availability and affordability of anti-malarials in a rural district in Kenya after implementation of a national subsidy scheme

October 27, 2011 - 07:26 -- Kabogo Ndegwa
Author(s): 
Smith N, Obala A, Simiyu C, Menya D, Khwa-Otsyula B, O'Meara W
Reference: 
Malaria Journal 2011, 10:316 (26 October 2011)

MalariaWorldAMFm-subsidized anti-malarials are considerably less expensive than unsubsidized AL, but the price difference between effective and ineffective therapies is still large.

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