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antimalarial

Open Access | The Role of Age and Exposure to Plasmodium falciparum in the Rate of Acquisition of Naturally Acquired Immunity: A Randomized Controlled Trial

March 30, 2012 - 13:34 -- Patrick Sampao
Author(s): 
Caterina Guinovart, Carlota Dobaño, Pedro L. Alonso, et al.
Reference: 
PLoS ONE 7(3): e32362

MalariaWorldWe used chemoprophylaxis to selectively control exposure to P. falciparum during different periods in infancy and explore the effect of age in the build-up of NAI, measured as risk of clinical malaria.

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Open Access | Priority setting for the implementation of artemisinin-based combination therapy policy in Tanzania: evaluation against the accountability for reasonableness framework

March 19, 2012 - 15:11 -- Patrick Sampao
Author(s): 
Amani Thomas Mori and Eliangiringa Amos Kaale
Reference: 
Implementation Science 2012, 7:18

MalariaWorldIn our understanding, this is the first study to evaluate priority-setting decisions for new drugs in Tanzania against the accountability for reasonableness framework.

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From the Cover: Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

March 14, 2012 - 14:20 -- Kabogo Ndegwa
Author(s): 
Joo Hwan No, Fernando de Macedo Dossin, Eric Oldfield, et al.
Reference: 
PNAS March 13, 2012 vol. 109 no. 11 4058-4063

MalariaWorldWe report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors.

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Open Access | Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action

March 14, 2012 - 06:14 -- Kabogo Ndegwa
Author(s): 
Mullie C, Jonet A, Degrouas C, Taudon N, Sonnet P
Reference: 
Malaria Journal 2012, 11:65 (8 March 2012)

MalariaWorldThe prominence of stereochemistry in the anti-malarial activity of 4-aminoalcohol quinoline derivatives is confirmed.

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Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics

March 13, 2012 - 14:07 -- Patrick Sampao
Author(s): 
Deepthi Pabbisetty, Anuradha Illendula, K.M. Muraleedharan, Amar G. Chittiboyina, John S. Williamson, Mitchell A. Avery, Bonnie A. Avery
Reference: 
Journal of Chromatography B, Volumes 889–890, 15 March 2012, Pages 123-129

MalariaWorldThe analysis was carried out on an Acquity™ UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) with a flow rate of 0.3 mL/min. The detection was performed on a triple quadrupole tandem mass spectrometer in positive electrospray ionization (ESI) mode.

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Open Access | Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

March 9, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Carrie A. Morris, Luis Lopez-Lazaro, Donald Jung, Janthima Methaneethorn, Stephan Duparc, Isabelle Borghini-Fuhrer, Rolf Pokorny, Chang-Sik Shin and Lawrence Fleckenstein
Reference: 
Am J Trop Med Hyg 2012 vol. 86 no. 3 489-495

MalariaWorldA multiple dose, parallel group study was conducted to assess for a drug-drug interaction between the pyronaridine/artesunate (PA) combination antimalarial and ritonavir.

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Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: A novel and potential antifolate lead for Pf-DHFR-TS inhibition

February 28, 2012 - 10:42 -- Patrick Sampao
Author(s): 
Prashant Gahtori, Surajit K. Ghosh, Pratap Parida, Anil Prakash, Kabita Gogoi, Hans Raj Bhat, Udaya Pratap Singh
Reference: 
Experimental Parasitology, Volume 130, Issue 3, March 2012, Pages 292-299

MalariaWorldFindings from the study disclose that a significant correlation was exist between in vitro results and in silico prediction (r2 = 0.543).

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Open Access | The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

February 23, 2012 - 15:53 -- Patrick Sampao
Author(s): 
Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth A. Winzeler, Robert E. Sinden, Didier Leroy
Reference: 
PLoS Medicine ,February 2012 Volume 9 Issue 2 e1001169

MalariaWorldThis study might reveal the potential of life-cycle–wide analyses of drugs for other pathogens with complex life cycles.

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Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts

February 22, 2012 - 15:01 -- Patrick Sampao
Author(s): 
J. Meyers, Marvin; E. Goldberg, Daniel
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 445-455(11)

MalariaWorldThis review will highlight some of the recent work in this field with a particular focus on target druggability and strategies for identifying plasmepsins inhibitors as effective antimalarial drugs.

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Falcipain Inhibition as a Promising Antimalarial Target

February 22, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Marco, Maria; Miguel Coteron, Jose
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 408-444(37)

MalariaWorldWe describe progress towards the discovery of promising falcipain inhibitors, in the light of their drug-like properties and the effect of the inhibition of several of these cysteine proteases.

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