A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity.
In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer.
We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of antimalarials in this setting.
Ethnopharmacological relevance. Although traditional antimalarial plant remedies in herbal markets are a very important component of the health care system in Ghana this has not been previously studied to allow for the formulation of effective strategy for malaria control in Ghana. Aim of study The main objective of the present study was to collect and analyse data on the antimalarial plant remedies in herbal markets in southern Ghana.
In the Republic of Korea (ROK), military antimalarial chemoprophylaxis was initiated in 1997. Although chemoprophylaxis reduces malaria cases, long-term chemoprophylaxis could increase resistance. In this study, the recurrence rate of vivax malaria was investigated.
A series of acridine derivatives were synthesised and their in vitro antimalarial activity was evaluated against one chloroquine-susceptible strain (3D7) and three chloroquine-resistant strains (W2, Bre1 and FCR3) of Plasmodium falciparum.
Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity.