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antimalarial

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

January 28, 2010 - 12:12 -- Kabogo Ndegwa
Author(s): 
Renate H. Hans, Eric M. Guantai, Carmen Lategan, Peter J. Smith, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal and Kelly Chibal
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 942-944

A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity.

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Open Access | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer

January 10, 2010 - 16:39 -- Ingeborg van Schayk
Author(s): 
John Schmieg, Guangli Yang, Richard W. Franck, and Moriya Tsuji
Reference: 
Journal of Biomedicine and Biotechnology, Volume 2010 (2010), Article ID 283612

In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer.

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Open Access| Residual Antimalarials in Malaria Patients from Tanzania – Implications on Drug Efficacy Assessment and Spread of Parasite Resistance

December 22, 2009 - 12:06 -- Ingeborg van Schayk
Author(s): 
Hodel EM, Kabanywanyi AM, Malila A, Zanolari B, Mercier T, et al.
Reference: 
PLoS ONE 4(12): e8184

We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of antimalarials in this setting.

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Traditional antimalarial phytotherapy remedies in herbal markets in southern Ghana

November 26, 2009 - 07:20 -- Patrick Sampao
Author(s): 
Alex Asase, Gloria Oppong-Mensah.
Reference: 
Journal of Ethnopharmacology, Volume 126, Issue 3, 10 December 2009, Pages 492-499, doi:10.1016/j.jep.2009.09.008

Ethnopharmacological relevance. Although traditional antimalarial plant remedies in herbal markets are a very important component of the health care system in Ghana this has not been previously studied to allow for the formulation of effective strategy for malaria control in Ghana. Aim of study The main objective of the present study was to collect and analyse data on the antimalarial plant remedies in herbal markets in southern Ghana.

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Recurrence rate of vivax malaria in the Republic of Korea

November 26, 2009 - 06:53 -- Kabogo Ndegwa
Author(s): 
Ki Tae Moon, Young Keun Kim, Dong Hoon Ko, Inho Park, Dong Chun Shin, Changsoo Kim.
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1245-1249, doi:10.1016/j.trstmh.2008.10.023

In the Republic of Korea (ROK), military antimalarial chemoprophylaxis was initiated in 1997. Although chemoprophylaxis reduces malaria cases, long-term chemoprophylaxis could increase resistance. In this study, the recurrence rate of vivax malaria was investigated.

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Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin

November 13, 2009 - 11:05 -- Ingeborg van Schayk
Author(s): 
Lucie Guetzoyan, Xiao-Min Yu, Florence Ramiandrasoa, Stéphanie Pethe, Christophe Rogier, Bruno Pradines, Thierry Cresteil, Martine Perrée-Fauvet, Jean-Pierre Mahy
Reference: 
Bioorganic & Medicinal Chemistry , Volume 17, Issue 23, 1 December 2009, Pages 8032-8039

A series of acridine derivatives were synthesised and their in vitro antimalarial activity was evaluated against one chloroquine-susceptible strain (3D7) and three chloroquine-resistant strains (W2, Bre1 and FCR3) of Plasmodium falciparum.

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Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

November 13, 2009 - 10:58 -- Ingeborg van Schayk
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Author(s): 
Desmond Slade, Ahmed M. Galal, Waseem Gul, Mohamed M. Radwan, Safwat A. Ahmed, Shabana I. Khan, Babu L. Tekwani, Melissa R. Jacob, Samir A. Ross, Mahmoud A. ElSohly
Reference: 
Bioorganic & Medicinal Chemistry, Volume 17, Issue 23, 1 December 2009, Pages 7949-7957

Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity.

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