The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10241 malaria professionals are enjoying the free benefits of MalariaWorld today

antimalarial

A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

July 31, 2012 - 12:49 -- Kabogo Ndegwa
Author(s): 
Vincent Thomas, Ana Góis, Bruce Ritts, Peter Burke, Thomas Hänscheid, Gerald McDonnell
Reference: 
PLoS ONE 7(7): e41006

MalariaWorldThe described HLC assay is simple and easy to perform and may have the potential to be used as an additional tool to screen antimalarial drugs for their hemozoin inhibiting activity.

Medical Condition: 
Medical Treatment: 

Not Open Access | Novel Drug Targets in Malaria Parasite with Potential to Yield Antimalarial Drugs with Long Useful Therapeutic Lives

July 12, 2012 - 08:37 -- Patrick Sampao
Author(s): 
W. Muregi, Francis; Nyakio Wamakima, Hannah; T. Kimani, Francis
Reference: 
Current Pharmaceutical Design, Volume 18, Number 24, August 2012 , pp. 3505-3521(17)

MalariaWorldThe present review explores novel drug targets within the malaria parasite that may be exploited in the search for novel drugs that possess long and UTLs.

Medical Condition: 
Medical Treatment: 

NOT Open Access | Antimalarial Efficacy of a Quantified Extract of Nauclea pobeguinii Stem Bark in Human Adult Volunteers with Diagnosed Uncomplicated falciparum Malaria. Part 2: A Clinical Phase IIB Trial

June 1, 2012 - 08:42 -- Patrick Sampao
Author(s): 
Kahunu Mesia, Lutete Tona, Arnold J. Vlietinck, et al.
Reference: 
Planta Med -0031-1298488

MalariaWorldThe study showed a significant decreased parasitaemia in patients treated with PR 29 CT1 and artesunate-amodiaquine with adequate clinical parasitological responses (APCR) at day 14 of 87.9 and 96.9 %, respectively.

Medical Condition: 
Medical Treatment: 

NOT Open Access | Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

June 1, 2012 - 08:36 -- Patrick Sampao
Author(s): 
Ariel H. Achtman, Sandra Pilat, Louis Schofield, et al.
Reference: 
Sci Transl Med 23 May 2012: Vol. 4, Issue 135, p. 135ra64

MalariaWorldWe assessed the potential for host-directed therapy of severe malaria of a new class of anti-inflammatory drugs, the innate defense regulator (IDR) peptides, based on host defense peptides.

Medical Condition: 
Medical Treatment: 

NOT Open Access | Review: Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa

May 23, 2012 - 12:54 -- Patrick Sampao
Author(s): 
Gaurvika ML Nayyar, Joel G Breman, Paul N Newton, James Herrington
Reference: 
The Lancet Infectious Diseases, Volume 12, Issue 6, June 2012, Pages 488-496

MalariaWorldWe reviewed published and unpublished studies reporting chemical analyses and assessments of packaging of antimalarial drugs.

Medical Treatment: 

NOT Open Access | Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India

May 21, 2012 - 14:52 -- Patrick Sampao
Author(s): 
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinkar Sahal, et al.
Reference: 
Journal of Ethnopharmacology, Volume 141, Issue 3, 14 June 2012, Pages 796-802

MalariaWorldThese results provide validation for the traditional usage of some medicinal plants against malaria in Dharmapuri region, Tamil Nadu, India.

Country: 
Region: 
Medical Treatment: 

Restricted | Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents

May 8, 2012 - 13:48 -- Kabogo Ndegwa
Author(s): 
Claire Tacon, Eric M. Guantai, Peter J. Smith, Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 2, 15 January 2012, Pages 893–902

MalariaWorldHerein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems.

Medical Condition: 
Medical Treatment: 

Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study

April 27, 2012 - 12:37 -- Patrick Sampao
Author(s): 
R McGready, SJ Lee, FH Nosten, et al.
Reference: 
The Lancet Infectious Diseases, Volume 12, Issue 5, May 2012, Pages 388-396

MalariaWorldWe analysed all antenatal records of women in the first trimester of pregnancy attending Shoklo Malaria Research Unit antenatal clinics from May 12, 1986, to Oct 31, 2010.

Person: 
Medical Condition: 
Medical Treatment: 

Hydroxyl mechanism of the antimalarial effect of artemisinin and its analogs

April 17, 2012 - 14:46 -- Patrick Sampao
Author(s): 
E. T. Denisov and T. G. Denisova
Reference: 
Russian Chemical Bulletin, 2011, Volume 60, Number 7, Pages 1421-1435

MalariaWorldKinetic schemes for the intramolecular oxidation of four artemisinin analogs, which are used as drugs against malaria, were developed.

Technology: 
Medical Treatment: 

Ethnomedicinal knowledge, belief and self-reported practice of local inhabitants on traditional antimalarial plants and phytotherapy

April 13, 2012 - 15:09 -- Patrick Sampao
Author(s): 
Kaliyaperumal Karunamoorthi, Endrias Tsehaye
Reference: 
Journal of Ethnopharmacology, Volume 141, Issue 1, 7 May 2012, Pages 143-150

MalariaWorldThis paper reveals the trend of knowledge and practice of traditional antimalarial plants (TAPs) to prevent/treat malaria.

Medical Treatment: 

Pages

Subscribe to RSS - antimalarial