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RDTs

Open Access | Improving Rational Treatment of Malaria: Perceptions and Influence of RDTs on Prescribing Behaviour of Health Workers in Southeast Nigeria

February 7, 2011 - 08:08 -- Kabogo Ndegwa
Author(s): 
Benjamin S. C. Uzochukwu, Emmanuel Onwujekwe, Nkoli N. Ezuma, Ogochukwu P. Ezeoke, Miriam O. Ajuba, Florence T. Sibeudu
Reference: 
PLoS ONE 6(1): e14627

RDT-supported malaria diagnosis may have led to the overprescription of ACTs, with the drug being prescribed to people with RDT-negative results.

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Health Workers' Use of Malaria Rapid Diagnostic Tests (RDTs) to Guide Clinical Decision Making in Rural Dispensaries, Tanzania

December 2, 2010 - 12:29 -- Patrick Sampao
Author(s): 
M. Irene Masanja, Meredith McMorrow, Elizeus Kahigwa, S. Patrick Kachur, and Peter D. McElroy
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1238 - 1241.

We assessed health worker malaria treatment practices after the introduction of RDTs in peripheral health facilities without microscopy.

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Open Access | Implementing school malaria surveys in Kenya: towards a national surveillance system

November 3, 2010 - 08:46 -- Kabogo Ndegwa
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Author(s): 
Gitonga CW, Karanja PN, Kihara J, Mwanje M, Juma E, Snow RW, Noor AM, Brooker S
Reference: 
Malaria Journal 2010, 9:306 (30 October 2010)

School malaria surveys provide a rapid, cheap and sustainable approach to malaria surveillance which can complement household surveys, and in Kenya, show that large areas of the country do not merit any direct school-based control, but schoolbased interventions, coupled with strengthened communitybased strategies, are warranted in western and coastal Kenya.

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Open Access | Performance of HRP-2 based rapid diagnostic test for malaria and its variation with age in an area of intense malaria transmission in southern Tanzania

October 28, 2010 - 08:35 -- Kabogo Ndegwa
Author(s): 
Laurent A, Schellenberg J, Shirima K, Ketenda SC, Alonso PL, Mshinda H, Tanner M, Schellenberg D
Reference: 
Malaria Journal 2010, 9:294 (26 October 2010)

These results suggest that the performance of HRP-2 tests in areas of intense malaria transmission varies by age and the prevalence of P. falciparum infection. The particularly low specificity among children will lead to the over-estimation of malaria infection prevalence in this group.

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Open Access | A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province, Zambia

October 8, 2010 - 07:21 -- Kabogo Ndegwa
Author(s): 
Stresman GH, Kamanga A, Moono P, Hamapumbu H, Mharakurwa S, Kobayashi T, Moss WJ, Shiff C
Reference: 
Malaria Journal 2010, 9:265 (4 October 2010)

This pilot project showed that active case detection is feasible and can identify reservoirs of asymptomatic infection. A larger sample size, data over multiple low transmission seasons, and in areas with different transmission dynamics are needed to further validate this approach.

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Open Access | Editorial Commentary: Risks and Benefits of Targeted Malaria Treatment Based on Rapid Diagnostic Test Results

August 6, 2010 - 12:54 -- Kabogo Ndegwa
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Author(s): 
Anders Björkman and Andreas Mårtensson
Reference: 
Clinical Infectious Diseases 1 September 2010, Vol. 51, No. 5: 512-514

In this issue of Clinical Infectious Diseases, d’Acremont et al [1] importantly address the clinical safety of withholding antimalarial treatment in febrile children who have a negative result for one of the newly developed rapid diagnostic tests (RDTs) for malaria.

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Open Access | Withholding Antimalarials in Febrile Children Who Have a Negative Result for a Rapid Diagnostic Test

August 6, 2010 - 08:30 -- Kabogo Ndegwa
Author(s): 
Valérie d’Acremont, Aggrey Malila, Ndeniria Swai, Robert Tillya, Judith Kahama‐Maro, Christian Lengeler, and Blaise Genton
Reference: 
Clinical Infectious Diseases 1 September 2010, Vol. 51, No. 5: 506-511

Not giving antimalarial drugs in febrile children who had a negative RDTm result was safe, even in an area highly endemic for malaria. Our study provides evidence for treatment recommendations based on parasitological diagnosis in children <5 years old.

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Open Access | Buffer substitution in malaria rapid diagnostic tests causes false-positive results

July 26, 2010 - 14:16 -- Kabogo Ndegwa
Author(s): 
Gillet P, Mori M, Van den Ende J, Jacobs J
Reference: 
Malaria Journal 2010, 9:215 (22 July 2010)

Replacement of the RDT kit's dedicated buffer by saline, distilled water and tap water can cause false-positive test results.

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Open Access | Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi

July 21, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D
Reference: 
Malaria Journal 2010, 9:209 (20 July 2010)

The results of this evaluation, combined with other published data and global recommendations, have been used to select RDTs for national scale-up. In addition, the study identified some key issues that need to be further delineated: the low field specificity of RDTs, variable RDT performance by different cadres of health workers and the need for a robust quality assurance system.

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Open Access | Laboratory evaluation on the sensitivity and specificity of a novel and rapid detection method for malaria diagnosis based on magneto-optical technology (MOT)

July 21, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Mens PF, Matelon RJ, Nour BY, Newman DM, Schallig HD
Reference: 
Malaria Journal 2010, 9:207 (19 July 2010)

Although MOT sensitivity and specificity are currently not yet at a competing level compared to other diagnostic test, such as PCR and RDTs, it has a potential to rapidly screen patients for malaria in endemic as well as non-endemic countries.

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