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antimalarial

NOT Open Access | Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity

July 16, 2019 - 16:49 -- NOT Open Access
Author(s): 
Edrous Alamer, Victor H. Carpio, Robin Stephens, et al.
Reference: 
Parasitology Research, July 2019, Volume 118, Issue 7, pp 2277–2285

Malaria-associated bacteremia accounts for up to one-third of deaths from severe malaria, and non-typhoidal Salmonella (NTS) has been reported as a major complication of severe malarial infection.

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Identification and Deconvolution of Cross-Resistance Signals from Antimalarial Compounds Using Multidrug-Resistant Plasmodium falciparum Strains

January 28, 2015 - 16:16 -- Open Access
Author(s): 
Monika Chugh, Christian Scheurer, Xavier C. Ding, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 1110-1118

Plasmodium falciparum, the most deadly agent of malaria, displays a wide variety of resistance mechanisms in the field.

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Recent progress in the development of anti-malarial quinolones

September 4, 2014 - 13:03 -- Open Access
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Author(s): 
Beteck RM, Smit FJ, Haynes RK, N'Da DD
Reference: 
Malaria Journal 2014, 13 :339 (30 August 2014)

Available anti-malarial tools have over the ten-year period, 2002 to 2012, dramatically reduced the number of fatalities attributed to malaria, from one million to less than six-hundred and thirty thousand.

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NOT Open Access | Endoperoxide polyketides from a Chinese Plakortis simplex: Further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes

August 27, 2014 - 14:35 -- NOT Open Access
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Author(s): 
Giuseppina Chianese, Marco Persico, Caterina Fattorusso, et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 22, Issue 17, 1 September 2014, Pages 4572–4580

Chemical investigation of the organic extract obtained from the sponge Plakortis simplex collected in the South China Sea afforded five new polyketide endoperoxides (2 and 4–7), along with two known analogues (1 and 3).

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NOT Open Access | Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights from Computational Modeling and Clinical Case Reports

July 16, 2014 - 07:53 -- NOT Open Access
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Author(s): 
Gilles Cottrell, Lise Musset, Véronique Hubert, Jacques Le Bras, Jérôme Clain, the Atovaquone-Proguanil Treatment Failure Study Group
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4504-4514

The usefulness of atovaquone-proguanil (AP) as an antimalarial treatment is compromised by the emergence of atovaquone resistance during therapy.

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Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity

November 11, 2013 - 14:15 -- Open Access
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Author(s): 
Russell B, Malleret B, Suwanarusk R, Anthony C, Kanlaya S, Lau YL, Woodrow CJ, Nosten F, Renia L.
Reference: 
Antimicrob Agents Chemother. 2013 Oct;57(10):5170-4
MalariaWorld

Ex vivo antimalarial sensitivity testing in human malaria parasites has largely depended on microscopic determination of schizont maturation.

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NOT Open Access | One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bio-evaluation as antimalarial and anti-HIV agents

September 3, 2012 - 07:41 -- Kabogo Ndegwa
Author(s): 
Seerat Fatima, Anindra Sharma, Reshu Saxena, Rajkamal Tripathi, Sanjeev K. Shukla, Swaroop Kumar Pandey, Renu Tripathi, Rama P. Tripathi
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 195–204

MalariaWorldAn efficient one pot synthesis of a series of pluripotent (E)-1-(3-methyl-5-aryl-7-styryl-5H-thiazolo[3,2-a]pyrimidin-6-yl)-3-arylprop-2-en-1-ones is reported.

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Parasite-based malaria diagnosis: Are Health Systems in Uganda equipped enough to implement the policy?

August 27, 2012 - 14:15 -- Patrick Sampao
Author(s): 
Kyabayinze DJ, Achan J, Nakanjako D, Mpeka B, Mawejje H, Mugizi R, Kalyango JN, D'Alessandro U, Talisuna AO, Van Geertruden J
Reference: 
BMC Public Health 2012, 12:695 (24 August 2012)

MalariaWorldThis study assessed the health systems capacity to absorb PMD at primary health care facilities in Uganda.

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Not Open Access | Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp. BCC45596

August 13, 2012 - 14:51 -- Patrick Sampao
Author(s): 
Khomsan Supong, Chitti Thawai, Khanit Suwanborirux, Wilunda Choowong, Sumalee Supothina, Pattama Pittayakhajonwut
Reference: 
Phytochemistry Letters, Volume 5, Issue 3, September 2012, Pages 651-656

MalariaWorldThese compounds (1–4) exhibited potent anti-Plasmodium palcifarum K1 strain with IC50 values in a range of 0.0534–2.93 μg/mL and anti-Mycobacterium tuberculosis with minimum inhibition concentrations (MICs) in a range of 3.13–12.50 μg/mL. Cytotoxicity against KB, MCF-7, NCI-H187, and Vero cells was also evaluated.

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