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Short Communication: Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

July 19, 2010 - 12:01 -- Patrick Sampao
Perri Pleeter, Jacqueline K. Lekostaj, Paul D. Roepe
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 158-161

We utilize the recent successful overexpression of recombinant Plasmodium falciparum multi-drug resistance transporter, purification and reconstitution of the protein, and a novel high affinity chloroquine analogue to probe hypothesized interaction between the transporter and quinoline drugs.

Medical Condition: 
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