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β-peroxides

6-(4′-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: A new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice

July 15, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Chandan Singh, Ved Prakash Verma, Niraj Krishna Naikade, Ajit Shankar Singh, Mohammad Hassam, Sunil. K. Puri
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 20, Issue 15, 1 August 2010, Pages 4459-4463

A new series of 6-(4′-aryloxy-phenyl)vinyl-1,2,4-trioxanes 10a–d, 11a–d, and 12a–d have been synthesized and evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

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