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antiplasmodial

Not Open Access |The antiplasmodial activity of norcantharidin analogs

October 23, 2012 - 17:25 -- Patrick Sampao
Author(s): 
Joanna Bajsa, Adam McCluskey, Christopher P. Gordon, Scott G. Stewart, Timothy A. Hill, Rajnish Sahu, Stephen O. Duke, Babu L. Tekwani
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 22, 15 November 2010, Pages 6688-6695

MalariaWorldThe antiplasmodial activities of sixty norcantharidin analogs were tested in vitro against a chloroquine sensitive (D6, Sierra Leone) and chloroquine resistant (W2) strains of Plasmodium falciparum.

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Implication of Glutathione in the In Vitro Antiplasmodial Mechanism of Action of Ellagic Acid

October 8, 2012 - 08:56 -- Kabogo Ndegwa
Author(s): 
Patrice Njomnang Soh, Benoit Witkowski, Amandine Gales, Eric Huyghe, Antoine Berry, Bernard Pipy, Françoise Benoit-Vical
Reference: 
PLoS ONE 7(9): e45906

MalariaWorldThe search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to current drugs. Ellagic acid (EA) is a polyphenol, recently found in various plant products, that has effective antimalarial activity in vitro and in vivo without toxicity.

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NOT Open Access | Synthesis and comparison of antiplasmodial activity of (+), (−) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline

September 19, 2012 - 12:55 -- Kabogo Ndegwa
Author(s): 
Chiara Rusconi, Nadia Vaiana, Manolo Casagrande, Nicoletta Basilico, Silvia Parapini, Donatella Taramelli, Sergio Romeo, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 19, 1 October 2012, Pages 5980–5985

MalariaWorldRecently the N-(−)-lupinyl-derivative of 7-chloro-4-aminoquinoline ((−)-AM-1; 7-chloro-4-{N-[(1S,9aR)(octahydro-2H-quinolizin-1-yl)methyl]amino}quinoline) showed potent in vitro and in vivo activity against both Chloroquine susceptible and resistant strains of Plasmodium falciparum.

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NOT Open Access | Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B

September 11, 2012 - 07:20 -- Kabogo Ndegwa
Author(s): 
J.C. Quintana, A.M. Chacón, L. Vargas, C. Segura, J.M. Gutiérrez, J.C. Alarcón
Reference: 
Acta Tropica, Volume 124, Issue 2, November 2012, Pages 126–132

MalariaWorldThe antiplasmodial activity of phospholipases A2 (PLA2) isolated from different animals has been studied. We explored the in vitro anti Plasmodium falciparum effect of a fraction containing crotoxin, Crotoxin B and whole venom of the rattlesnake Crotalus durissus cumanensis.

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NOT Open Access | Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives

September 3, 2012 - 07:53 -- Kabogo Ndegwa
Author(s): 
Anita Cohen, Pierre Verhaeghe, Maxime D. Crozet, Sébastien Hutter, Pascal Rathelot, Patrice Vanelle, Nadine Azas
Reference: 
European Journal of Medicinal Chemistry, Volume 55, September 2012, Pages 315–324

MalariaWorldA series of naphtho[2,1-d]thiazoles was prepared in good yields under microwave irradiation with an original protocol combining tandem direct arylation and intramolecular Knoevenagel reaction on 1,3-thiazole derivatives.

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Not Open Access | In vitro antiplasmodial activity of marine sponge Stylissa carteri associated bacteria against Plasmodium falciparum

August 13, 2012 - 14:43 -- Patrick Sampao
Author(s): 
Samuel Jacob Inbaneson, Sundaram Ravikumar
Reference: 
Asian Pacific Journal of Tropical Disease, Volume 2, Issue 5, October 2012, Pages 370-374

MalariaWorldTo identify the possible antiplasmodial drugs from bacteria associated with marine sponge Stylissa carteri (S. carteri).

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Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides

August 3, 2012 - 07:04 -- Kabogo Ndegwa
Author(s): 
Kaushik NK, Sharma J, Sahal D
Reference: 
Malaria Journal 2012, 11:256 (1 August 2012)

MalariaWorldGood selectivity (>35), good resistance index (1.1) and low cytotoxicity indicate the promise of DeltaFd against malaria.

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Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area

July 5, 2012 - 11:10 -- Kabogo Ndegwa
Author(s): 
Dell'Agli M, Sanna C, Rubiolo P, Basilico N, Colombo E, Scaltrito MM, Ndiath O, Maccarone L, Taramelli D, Bicchi C, Ballero M, Bosisio E
Reference: 
Malaria Journal 2012, 11:219 (2 July 2012)

MalariaWorldThis study provides evidence for the use of essential oils for treating malaria and fighting the vector at both the larval and adult stages.

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Not Open Access | In vitro antiplasmodial activity of Clathria vulpina sponge associated bacteria against Plasmodium falciparum

July 2, 2012 - 13:11 -- Patrick Sampao
Author(s): 
Samuel Jacob Inbaneson, Sundaram Ravikumar
Reference: 
Asian Pacific Journal of Tropical Disease, Volume 2, Issue 4, August 2012, Pages 319-323

MalariaWorldThe C. vulpina samples were collected from Thondi coast and subjected to enumeration and isolation of associated bacteria. Filtered and sterilized extracts (100, 50, 25, 12.5, 6.25 and 3.125 μg/mL) from isolated bacterial strains were screened for antiplasmodial activity against Plasmodium falciparum.

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NOT Open Access | In vitro antiplasmodial activity of ethanolic extracts of South Indian medicinal plants against Plasmodium falciparum

May 23, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi
Reference: 
Asian Pacific Journal of Tropical Disease, Volume 2, Issue 3, March 2012, Pages 180-183

MalariaWorldTo explore the antiplasmodial potential ofCatharanthus roseus L (C. roseus), Coccinea grandis (C. grandis), Thevetia peruviana (T. peruviana), Prosopis juliflora (P. juliflora), Acacia nilotica (A. nilotica), Azadirachta indica (A. indica) (Abr. Juss) and Morinda pubescens (M. pubescens).

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