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genome

Open Access | Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

September 17, 2010 - 13:45 -- Patrick Sampao
Author(s): 
Hunt P., Martinelli A., et al.
Reference: 
BMC Genomics 2010, 11:499 (16 September 2010)

Here, we combine in vivo experimental evolution, a rapid genetic strategy and whole genome re-sequencing to identify the precise genetic basis of artemisinin resistance in a lineage of the rodent malaria parasite, Plasmodium chabaudi.

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Open Access | Genome mapping and characterization of the Anopheles gambiae heterochromatin

August 6, 2010 - 14:29 -- Patrick Sampao
Author(s): 
Sharakhova M, George P, Brusentsova , Leman SC, Bailey JA, Smith CD, Sharakhov
Reference: 
BMC Genomics 2010, 11:459 (4 August 2010)

Our results demonstrate that Anopheles polytene chromosomes and whole-genome shotgun assembly render the mapping and characterization of a significant part of heterochromatic scaffolds a possibility.

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Open Access | Commentary: Genome-wide association studies in Plasmodium species

July 15, 2010 - 09:43 -- Patrick Sampao
Author(s): 
Bridget Penman, Caroline Buckee, Sunetra Gupta and Sean Nee
Reference: 
BMC Biology 2010, 8:90

A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity.

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