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artemisinin combination therapy (ACT)

The impact of rapid malaria diagnostic tests upon anti-malarial sales in community pharmacies in Gwagwalada, Nigeria

November 6, 2013 - 08:12 -- Open Access
Author(s): 
Ikwuobe JO, Faragher BE, Alawode G, Lalloo DG
Reference: 
Malaria Journal 2013, 12 :380 (30 October 2013)
MalariaWorld

The study highlights the enormous potential for improving appropriate prescription of anti-malarials in pharmacies and preventing unnecessary use of artemisinin combination therapy (ACT).

Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients

July 17, 2013 - 12:32 -- Open Access
Author(s): 
Staehli Hodel EM, Guidi M, Zanolari B, Mercier T, Duong S, Kabanywanyi AM, Ariey F, Buclin T, Beck H, Decosterd LA, Olliaro P, Genton B, Csajka C
Reference: 
Malaria Journal 2013, 12:235 (10 July 2013)
MalariaWorld

The marked variability in the disposition of different forms of ACT remained largely unexplained by the available covariates.

Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

February 26, 2013 - 08:32 -- Open Access
Author(s): 
Lombard MC, N'Da DD, Tran Van Ba C, Wein S, Norman J, Wiesner L, Vial H
Reference: 
Malaria Journal 2013, 12:71 (21 February 2013)
MalariaWorld

These compounds provide a new class of so desperately needed anti-malarial drug. Despite a short half-life and moderate oral bioavailability, this class of compounds was able to cure malaria in mice at very low dosages implicating extremely active metabolites.

Dried Whole Plant Artemisia annua as an Antimalarial Therapy

January 2, 2013 - 06:35 -- Open Access
Author(s): 
Mostafa A. Elfawal, Melissa J. Towler, Nicholas G. Reich, Douglas Golenbock, Pamela J. Weathers, Stephen M. Rich
Reference: 
PLoS ONE 7(12): e52746
MalariaWorld

Drugs are primary weapons for reducing malaria in human populations.

Scaling-up malaria treatment: a review of the performance of different providers

December 18, 2012 - 12:12 -- Open Access
Author(s): 
Kamal-Yanni MM, Potet J, Saunders PM
Reference: 
Malaria Journal 2012, 11:414 (12 December 2012)
MalariaWorld

The evidence shows that there is no short-cut to investing in training and supervision of providers, or in treating malaria within a public health context rather than as a separate disease.

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Open-label trial of three dosage regimens of fixeddose combination of artemisinin and naphthoquine for treating uncomplicated falciparum malaria in calabar, Nigeria

December 13, 2012 - 07:49 -- Open Access
Author(s): 
Meremikwu MM, Odey F, Oringanje C, Oyo-ita A, Effa E, Esu EB, Eyam E, Oduwole O, Asiegbu V, Alaribe A, Ezedinachi EN
Reference: 
Malaria Journal 2012, 11:413 (11 December 2012)
MalariaWorld

Concerns for emergence of parasite resistance due the use of artemisinin-naphthoquine as single dose regimen is likely to compromise the usefulness of this potentially important combination treatment.

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Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal

December 6, 2012 - 07:25 -- Open Access
Tags: 
Author(s): 
Brasseur P, Vaillant MT, Olliaro PL
Reference: 
Malaria Journal 2012, 11:402 (5 December 2012)
MalariaWorld

The study was successful in quantifying and characterizing known reactions and has benchmarking value.

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Genotyping of Plasmodium falciparum using antigenic polymorphic markers and to study anti-malarial drug resistance markers in malaria endemic areas of Bangladesh

November 26, 2012 - 07:39 -- Open Access
Author(s): 
Akter J, Thriemer K, Khan WA, Sullivan DJ, Noedl H, Haque R
Reference: 
Malaria Journal 2012, 11:386 (22 November 2012
MalariaWorld

The parasite population retains high population diversity despite hypo-endemic transmission with retention, but decrease in the chloroquine-resistant allele and Pfmdr1 resistant alleles in the Chittagong Hill Tracts of Bangladesh.

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Management of imported malaria in Europe

September 18, 2012 - 08:08 -- Kabogo Ndegwa
Author(s): 
Askling HH, Bruneel F, Buchard G, Castelli F, Chiodini PL, Grobusch MP, Lopez-Vélez R, Paul M, Petersen E, Popescu C, Ramharter M, Schlagenhauf P
Reference: 
Malaria Journal 2012, 11:328 (17 September 2012)

MalariaWorldIn this position paper, the European Society for Clinical Microbiology and Infectious Diseases, Study Group on Clinical Parasitology, summarizes main issues regarding the management of imported malaria cases.

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Trends in availability and prices of subsidized ACT over the first year of the AMFm: evidence from remote regions of Tanzania

August 30, 2012 - 08:08 -- Kabogo Ndegwa
Author(s): 
Yadav P, Cohen JL, Alphs S, Arkedis J, Larson P, Massaga J, Sabot O
Reference: 
Malaria Journal 2012, 11:299 (28 August 2012)

MalariaWorldThe AMFm led to large increases in availability of low priced ACT in Tanzania, with no significant variation in availability based on remoteness.

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