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artemisinin combination therapy (ACT)

Scaling up malaria intervention “packages” in Senegal: using cost effectiveness data for improving allocative efficiency and programmatic decision-making

April 11, 2018 - 14:53 -- Open Access
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Author(s): 
Sophie Faye, Altea Cico, Alioune Badara Gueye, Elaine Baruwa, Benjamin Johns, Médoune Ndiop and Martin Alilio
Reference: 
Malaria Journal 2018 17:159, 10 April 2018

Senegal’s choice of deploying malaria interventions by packages seems to be effectively targeting high burden areas with a wide range of interventions.

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Failure of dihydroartemisinin-piperaquine treatment of uncomplicated Plasmodium falciparum malaria in a traveller coming from Ethiopia

November 8, 2016 - 17:12 -- Open Access
Author(s): 
Federico Gobbi, Dora Buonfrate, Michela Menegon, Gianluigi Lunardi, Andrea Angheben, Carlo Severini, Stefania Gori and Zeno Bisoffi
Reference: 
Malaria Journal 2016 15:525, 3 November 2016

In consideration of the growing number of cases of resistance to ACT, it is important to consider a possible recrudescence, that can manifest also several weeks after treatment.

Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether–lumefantrine drug pressure on Plasmodium falciparum populations in Senegal

August 30, 2016 - 15:00 -- Open Access
Author(s): 
Aminata Mbaye, Baba Dieye, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2016 15:433, 25 August 2016

This study has shown an increase in sensitivity over the span of two transmission seasons, marked by an increase in the WT alleles at pfmdr1.

Oral artemisinin monotherapy removal from the private sector in Eastern Myanmar between 2012 and 2014

May 25, 2016 - 17:37 -- Open Access
Author(s): 
Hnin Su Su Khin, Tin Aung, Aung Thi and Chris White
Reference: 
Malaria Journal 2016 15:286, 23 May 2016

The findings point to the successful design and implementation of a strategy to rapidly remove oral AMT from pharmacies, general retailers and mobile providers and to replace its use with quality-assured ACT.

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Treatment outcomes in a safety observational study of dihydroartemisinin/piperaquine (Eurartesim®) in the treatment of uncomplicated malaria at public health facilities in four African countries

January 29, 2016 - 18:46 -- Open Access
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Author(s): 
Alexander Adjei, Solomon Narh-Bana, Margaret Gyapong, et al.
Reference: 
Malaria Journal 2016 15:43, 27 January 2016

DHA-PQ was effective and well tolerated in the treatment of uncomplicated malaria and provides an excellent alternative first-line ACT in sub-Saharan Africa.

Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children

January 29, 2016 - 18:36 -- Open Access
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Author(s): 
Julian Muwanguzi, Gisela Henriques, Patrick Sawa, Teun Bousema, Colin J. Sutherland and Khalid B. Beshir
Reference: 
Malaria Journal 2016 15:36, 22 January 2016

This study contributes to the ongoing surveillance of suspected artemisinin resistance parasites in Africa by providing baseline prevalence of k13-propeller mutations in western Kenya with samples collected from a longitudinal study.

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Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study

November 26, 2015 - 05:48 -- Open Access
Author(s): 
Offianan Toure, Stephen Rulisa, Neena Valecha, et al.
Reference: 
Malaria Journal 2015, 14:469 (25 November 2015)

The findings from this study showed that FDC of arterolane maleate and PQP effectively cures P. falciparum malaria and attains acceptable level of cure by day 28 in paediatric patients.

Prompt access to effective malaria treatment among children under five in sub-Saharan Africa: a multi-country analysis of national household survey data

August 25, 2015 - 06:30 -- Open Access
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Author(s): 
Jui Shah, Jacques Emina, Erin Eckert, Yazoume Ye
Reference: 
Malaria Journal 2015, 14:329 (25 August 2015)

This study reveals that country of residence, maternal education, place of residence, and socio-economic status are key predictors of prompt access to malaria treatment.

Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia

June 2, 2015 - 06:34 -- Open Access
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Author(s): 
Moses Laman, Susan Aipit, Cathy Bona, Peter Siba, Leanne Robinson, Laurens Manning, Timothy Davis
Reference: 
Malaria Journal 2015, 14:219 (28 May 2015)

Clinical assessment of splenomegaly is imprecise compared with ultrasonography.

Effect of diagnostic testing on medicines used by febrile children less than five years in 12 malaria-endemic African countries: a mixed-methods study

May 12, 2015 - 11:11 -- Open Access
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Author(s): 
Emily Johansson, Peter W Gething, Helena Hildenwall, Bonnie Mappin, Max Petzold, Stefan Peterson, Katarina Selling
Reference: 
Malaria Journal 2015, 14:194 (10 May 2015)

Significant country variation was found in the effect of diagnostic testing on paediatric fever treatment at the population level, and qualitative results suggest the impact of diagnostic scale-up on treatment practices may not be straightforward in routine conditions given contextual factors (e.g., access to care, treatment-seeking behaviour or supply stock-outs).

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