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rapid diagnostic tests (RDTs)

Placental infections with histologically-confirmed Plasmodium falciparum are associated with adverse birth outcomes in India: a cross-sectional study

June 16, 2014 - 16:05 -- Open Access
Author(s): 
Ahmed R, Singh N, ter Kuile FO, Bharti P, Singh PP, Desai M, Udhayakumar V, Terlouw DJ
Reference: 
Malaria Journal 2014, 13 :232 (13 June 2014)

Malaria associated stillbirth and low birth weight in women with low protective immunity may result, at least in part, from a shortened gestation triggered by acute infection, stressing the importance of early malaria detection.

Medical Treatment: 

Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review

June 16, 2014 - 15:59 -- Open Access
Tags: 
Author(s): 
Ruizendaal E, Dierickx S, Peeters Grietens K, Schallig HD, Pagnoni F, Mens PF
Reference: 
Malaria Journal 2014, 13 :229 (12 June 2014)

Background

 

Malaria still causes high morbidity and mortality around the world, mainly in sub-Saharan Africa. Community case management of malaria (CCMm) by community health workers (CHWs) is one of the strategies to combat the disease by increasing access to malaria treatment. Currently, the World Health Organization recommends to treat only confirmed malaria cases, rather than to give presumptive treatment.

CCMm is generally well executed by CHWs, but there are several barriers for its success. Integrated CCM may overcome some of these barriers.

Medical Treatment: 

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests

February 14, 2014 - 08:57 -- Open Access
Author(s): 
Deme AB, Park DJ, Volkman SK, et al.
Reference: 
Malaria Journal 2014, 13 :34 (29 January 2014)

These results warrant deeper monitoring of the RDT target antigen diversity and emphasize that development of other essential genes as a target for diagnostic tools is critical.

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Medical Treatment: 

Lessons learned from the use of HRP-2 based rapid diagnostic test in community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso

February 14, 2014 - 08:41 -- Open Access
Author(s): 
Tiono AB, Ouédraogo A, Diarra A, Coulibaly S, Soulama I, Konaté AT, Barry A, Mukhopadhyay A, Sirima SB, Hamed K
Reference: 
Malaria Journal 2014, 13 :30 (27 January 2014)

The performance of HRP-2 test in detecting asymptomatic carriers of P. falciparum varied by age and parasite density.

Medical Treatment: 

Case investigation and reactive case detection for malaria elimination in northern Senegal

September 19, 2013 - 14:45 -- Open Access
Tags: 
Author(s): 
Littrell M, Sow G, Ngom A, Ba M, Mboup B, Dieye Y, Mutombo B, Earle D, Steketee R
Reference: 
Malaria Journal 2013, 12 :331 (17 September 2013)
MalariaWorld

The primary risk factor for malaria infection in the low transmission district of Richard Toll is travel.

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Medical Treatment: 

Performance of microscopy and RDTs in the context of a malaria prevalence survey in Angola: a comparison using PCR as the gold standard

August 22, 2013 - 08:39 -- Open Access
Author(s): 
Fançony C, Sebastião YV, Pires JE, Gamboa D, Nery SV
Reference: 
Malaria Journal 2013, 12:284 (13 August 2013)
MalariaWorld

Both microscopy and RDTs performed suboptimally when compared to PCR. False negativity could be associated with the low parasite density profile of the samples

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"Even if the test result is negative, they should be able to tell us what is wrong with us": a qualitative study of patient expectations of rapid diagnostic tests for malaria

July 26, 2013 - 08:37 -- Open Access
Tags: 
Author(s): 
Ansah EK, Reynolds J, Akanpigbiam S, Whitty CJ, Chandler CI
Reference: 
Malaria Journal 2013, 12:258 (22 July 2013)
MalariaWorld

Improvements in communication between the health worker and patient, particularly to explain the capabilities of the test and management of RDT negative cases, may both manage patient expectations and promote patient demand for test-driven diagnoses.

Medical Treatment: 

pLDH level of clinically isolated Plasmodium vivax and detection limit of pLDH based malaria rapid diagnostic test

June 5, 2013 - 12:56 -- Open Access
Author(s): 
Jang JW, Cho CH, Han ET, An SS, Lim CS
Reference: 
Malaria Journal 2013, 12:181 (3 June 2013)
MalariaWorld

The pLDH levels of P. vivax are the main explanation for the variations in the performance of pLDH-based RDTs.

Medical Treatment: 

Over-diagnosis of malaria by microscopy in the Kilombero Valley, Southern Tanzania: an evaluation of the utility and cost-effectiveness of rapid diagnostic tests

May 15, 2013 - 06:29 -- Open Access
Author(s): 
Harchut K, Standley C, Dobson A, Klaassen B, Rambaud-Althaus C, Althaus F, Nowak K
Reference: 
Malaria Journal 2013, 12:159 (10 May 2013)
MalariaWorld

Compared with RDTs, microscopy led to almost four out of five patients being over-diagnosed with malaria in this rural part of Tanzania.

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False Positivity of Non-Targeted Infections in Malaria Rapid Diagnostic Tests: The Case of Human African Trypanosomiasis

April 30, 2013 - 07:15 -- Open Access
Author(s): 
Philippe Gillet, Dieudonné Mumba Ngoyi, Albert Lukuka, Viktor Kande, Benjamin Atua, Johan van Griensven, Jean-Jacques Muyembe, Jan Jacobs, Veerle Lejon
Reference: 
PLoS Negl Trop Dis 7(4): e2180.
MalariaWorld

Specificity of some malaria RDT products in HAT was surprisingly low, and constitutes a risk for misdiagnosis of a fatal but treatable infection.

Medical Treatment: 

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