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rapid diagnostic tests (RDTs)

Costs and cost-effectiveness of a large-scale mass testing and treatment intervention for malaria in Southern Province, Zambia

May 22, 2015 - 13:02 -- Open Access
Author(s): 
Kafula Silumbe, Joshua O Yukich, Busiku Hamainza, Adam Bennett, Duncan Earle, Mulakwa Kamuliwo, Richard W Steketee, Thomas P Eisele, John M Miller
Reference: 
Malaria Journal 2015, 14:211 (20 May 2015)

The intervention appears to be highly cost-effective relative to World Health Organization thresholds for malaria burden reduction in Zambia as compared to no MTAT

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Determinants of malaria diagnostic uptake in the retail sector: qualitative analysis from focus groups in Uganda

March 2, 2015 - 18:45 -- Open Access
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Author(s): 
Jessica Cohen, Alex Cox, William Dickens, Kathleen Maloney, Felix Lam, Günther Fink
Reference: 
Malaria Journal 2015, 14:89 (21 February 2015)

In order to boost demand, these results suggest that private sector RDTs will have to be made convenient and affordable and that targeted behaviour change campaigns should strive to increase the perceived value of diagnosis.

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SMS photograph-based external quality assessment of reading and interpretation of malaria rapid diagnostic tests in the Democratic Republic of the Congo

February 11, 2015 - 16:22 -- Open Access
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Author(s): 
Pierre Mukadi, Philippe Gillet, Barbara Barbé, Jean Luamba, Albert Lukuka, Joris Likwela, Dieudonné Mumba, Jean-Jacques Muyembe, Pascal Lutumba, Jan Jacobs
Reference: 
Malaria Journal 2015, 14:26 (28 January 2015)

The present EQA revealed common errors in RDT reading and interpretation by HW in DRC.

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Strengthening malaria diagnosis and appropriate treatment in Namibia: a test of case management training interventions in Kavango Region

December 22, 2014 - 13:58 -- Open Access
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Author(s): 
Lourenço C, Kandula D, Haidula L, Ward A, Cohen JM
Reference: 
Malaria Journal 2014, 13 :508 (18 December 2014)

These changes show a reversal of improper case management practices over the six-month study period and demonstrate that implementing simple training interventions can have a significant, sustainable impact on the uptake of and adherence to malaria RDTs.

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Harmonization of malaria rapid diagnostic tests: best practices in labelling including instructions for use

December 22, 2014 - 13:49 -- Open Access
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Author(s): 
Jacobs J, Barbé B, Gillet P, Aidoo M, Serra-Casas E, Van Erps J, Daviaud J, Incardona S, Cunningham J, Visser T
Reference: 
Malaria Journal 2014, 13 :505 (17 December 2014)

The present document together with its additional files compiled proposes best practices in labelling and IFU for malaria RDTs.

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Composite endpoints for malaria case-management: not simplifying the picture?

December 18, 2014 - 09:18 -- Open Access
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Author(s): 
Cairns ME, Leurent B, Milligan PJ
Reference: 
Malaria Journal 2014, 13 :494 (13 December 2014)

Rapid diagnostic tests (RDTs) for infection with Plasmodium spp. offer two main potential advantages related to malaria treatment: 1) ensuring that individuals with malaria are promptly treated with an effective artemisinin-based combination therapy, and 2) ensuring that individuals without malaria do not receive an anti-malarial they do not need (and instead receive a more appropriate treatment).

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Comparison of a mobile phone-based malaria reporting system with source participant register data for capturing spatial and temporal trends in epidemiological indicators of malaria transmission collected by community health workers in rural Zambia

December 18, 2014 - 09:09 -- Open Access
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Author(s): 
Hamainza B, Killeen GF, Kamuliwo M, Bennett A, Yukich JO
Reference: 
Malaria Journal 2014, 13 :489 (12 December 2014)

The SMS reports captured malaria transmission trends with adequate accuracy and could be used for population-wide, continuous, longitudinal monitoring of malaria transmission.

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Circulating antibodies against Plasmodium falciparum histidine-rich proteins 2 interfere with antigen detection by rapid diagnostic tests

December 15, 2014 - 14:38 -- Open Access
Author(s): 
Mei-Fong Ho, Joanne Baker, James S McCarthy, et al.
Reference: 
Malaria Journal 2014, 13:480 (6 December 2014)

These observations indicate possible reduced sensitivity for diagnosis of P. falciparum malaria using PfHRP2-detecting RDTs among people with high levels of specific antibodies and low density infection, as well as possible interference with tests configured to detect soluble PfHRP2 in saliva or urine samples.

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Comparative performance of aldolase and lactate dehydrogenase rapid diagnostic tests in Plasmodium vivax detection

July 22, 2014 - 09:19 -- Open Access
Author(s): 
Dzakah EE, Kang K, Ni C, Tang S, Wang J, Wang J
Reference: 
Malaria Journal 2014, 13 :272 (11 July 2014)

Aldolase and LDH antigens perform differently in different P. vivax samples; hence there is a high risk of misdiagnosis when monoclonal antibodies are used against only one particular antigen in the test.

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NOT Open Access | Performance of a new gelled nested PCR test for the diagnosis of imported malaria: comparison with microscopy, rapid diagnostic test, and real-time PCR

June 18, 2014 - 14:57 -- NOT Open Access
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Author(s): 
Nuria Iglesias, Mercedes Subirats, Patricia Trevisi, Germán Ramírez-Olivencia, Pablo Castán, Sabino Puente & Carlos Toro
Reference: 
Parasitology Research, July 2014, Volume 113, Issue 7, pp 2587-2591

Microscopy and rapid diagnostic tests (RDTs) are the techniques commonly used for malaria diagnosis but they are usually insensitive at very low levels of parasitemia.

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