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rapid diagnostic tests (RDTs)

Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana

February 22, 2016 - 17:40 -- Open Access
Author(s): 
Linda Eva Amoah, Joana Abankwa and Akua Oppong
Reference: 
Malaria Journal 2016 15:101, 18 February 2016

A high number of P. falciparum parasites, which lack pfhrp2 exon 2 gene have been identified in two communities in Ghana.

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The complexities of simple technologies: re-imagining the role of rapid diagnostic tests in malaria control efforts

February 8, 2016 - 18:58 -- Open Access
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Author(s): 
Uli Beisel, René Umlauf, Eleanor Hutchinson and Clare I. R. Chandler
Reference: 
Malaria Journal 2016 15:64, 5 February 2016

These results underline that successful malaria diagnosis and treatment requires as much investment in general health infrastructure as it does in new technologies.

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Why do health workers give anti-malarials to patients with negative rapid test results? A qualitative study at rural health facilities in western Uganda

January 12, 2016 - 17:25 -- Open Access
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Author(s): 
Robin Altaras, Anthony Nuwa, Bosco Agaba, Elizabeth Streat, James Tibenderana, Clare Strachan
Reference: 
Malaria Journal 2016, 15:23 (11 January 2016)

The study found high provider adherence to RDT results, but that providers believed in certain clinical exceptions and felt they lacked alternative options.

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Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction

January 7, 2016 - 15:55 -- Open Access
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Author(s): 
Joaniter Nankabirwa, Adoke Yeka, Emmanuel Arinaitwe, Ruth Kigozi, Chris Drakeley, Moses Kamya, Bryan Greenhouse, Philip Rosenthal, Grant Dorsey, Sarah Staedke
Reference: 
Malaria Journal 2015, 14:528 (30 December 2015)

Malaria prevalence estimates varied with diagnostic test, age, and transmission intensity.

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An ultrasensitive reverse transcription polymerase chain reaction assay to detect asymptomatic low-density Plasmodium falciparum and Plasmodium vivax infections in small volume blood samples

December 29, 2015 - 16:26 -- Open Access
Author(s): 
Matthew Adams, Sudhaunshu Joshi, Christopher Plowe, et al.
Reference: 
Malaria Journal 2015, 14:520 (23 December 2015)

This ultrasensitive RT-PCR method is a robust, field-tested screening method that is vastly more sensitive than RDTs.

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Introducing rapid diagnostic tests for malaria into registered drug shops in Uganda: lessons learned and policy implications

November 18, 2015 - 14:07 -- Open Access
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Author(s): 
Anthony Mbonye, Sîan Clarke, Sham Lal, Clare Chandler, Eleanor Hutchinson, Kristian Hansen, Pascal Magnussen
Reference: 
Malaria Journal 2015, 14:448 (14 November 2015)

Introducing RDTs into drug shops was feasible and it increased appropriate treatment of malaria with artemisinin-based combination therapy.

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RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands

September 30, 2015 - 16:50 -- Open Access
Author(s): 
Nasserdine Papa Mze, Yaye Ndiaye, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2015, 14:373 (29 September 2015)

The utility of field-collected RDTs was validated as a source of DNA for genetic studies interrogating frequencies of drug resistance mutations, using two different molecular methods (PCR and High Resolution Melting).

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Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness

September 23, 2015 - 16:51 -- Open Access
Author(s): 
Ipsita Sinha, Nattwut Ekapirat, Arjen Dondorp, Charles Woodrow
Reference: 
Malaria Journal 2015, 14:362 (22 September 2015)

These studies show that plasma PfHRP2 can be assessed via a single RDT, with application of a plasma dilution of 1:5 or 1:10 providing useful diagnostic information to assist in patient management or clinical trial inclusion.

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NOT Open Access | Development of monoclonal antibodies against Plasmodium falciparum thioredoxin peroxidase 1 and its possible application for malaria diagnosis

May 30, 2015 - 10:23 -- NOT Open Access
Author(s): 
Hassan Hakimi, Yasuyuki Goto, Keisuke Suganuma, Jose Ma M. Angeles, Satoru Kawai, Noboru Inoue, Shin-ichiro Kawazu
Reference: 
Experimental Parasitology, Volume 154, July 2015, Pages 62–66

Rapid diagnostic tests (RDTs) have been considered as an ideal alternative for light microscopy to detect malaria parasites especially in remote areas.

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Variation in Plasmodium falciparum Histidine-Rich Protein 2 (Pfhrp2) and Plasmodium falciparum Histidine-Rich Protein 3 (Pfhrp3) Gene Deletions in Guyana and Suriname

May 30, 2015 - 10:20 -- Open Access
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Author(s): 
Sheila Akinyi Okoth, Joseph F. Abdallah, Venkatachalam Udhayakumar, et al.
Reference: 
PLoS ONE 10(5): e0126805

Guyana and Suriname have made important progress in reducing the burden of malaria.

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