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rapid diagnostic tests (RDTs)

Analytical sensitivity of current best-in-class malaria rapid diagnostic tests

March 28, 2017 - 15:31 -- Open Access
Author(s): 
Alfons Jimenez, Roxanne R. Rees-Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding
Reference: 
Malaria Journal 2017 16:128, 24 March 2017

The analytical sensitivity of P. vivax and Pan pLDH-based RDTs appears to vary considerably from product to product, and improvement of the limit-of-detection for P. vivax detecting RDTs is needed to match the performance of HRP2 and Pf pLDH-based RDTs for P. falciparum.

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False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

March 23, 2017 - 15:31 -- Open Access
Author(s): 
Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad
Reference: 
Malaria Journal 2017 16:123, 20 March 2017

This prospective study of RDT performance coincided with a decline in the intensity of malaria transmission in Kibirizi (fall in slide positivity from 46 to 3%).

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Performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia

January 24, 2017 - 17:59 -- Open Access
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Author(s): 
Banchamlak Tegegne, Sisay Getie, Wossenseged Lemma, Abu Naser Mohon and Dylan R. Pillai
Reference: 
Malaria Journal 2017 16:34, 19 January 2017

This study showed higher sensitivity of LAMP compared to microscopy and RDT for the detection of malaria in pregnancy.

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Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Tr

September 28, 2016 - 16:56 -- Open Access
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Author(s): 
Mwayiwawo Madanitsa, Linda Kalilani, Victor Mwapasa, Anna M. van Eijk, Carole Khairallah, Doreen Ali, Cheryl Pace, James Smedley, Kyaw-Lay Thwai, Brandt Levitt, Duolao Wang, Arthur Kang’ombe, Brian Faragher, Steve M. Taylor, Steve Meshnick, Feiko O. ter Kuile
Reference: 
PLoS Med 13(9): e1002124

Scheduled screening for malaria parasites with the current generation of RDTs three to four times during pregnancy as part of focused antenatal care was not superior to IPTp-SP in this area with high malaria transmission and high SP resistance and was associated with higher fetal loss and more malaria at delivery.

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Field evaluation of diagnostic performance of malaria rapid diagnostic tests in western Kenya

September 13, 2016 - 17:24 -- Open Access
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Author(s): 
Elizabeth W. Wanja, Nickline Kuya, Collins Moranga, Mark Hickman, Jacob D. Johnson, Carolyne Moseti, Lalaine Anova, Bernhards Ogutu and Colin Ohrt
Reference: 
Malaria Journal 2016 15:456, 7 September 2016

The performance of the evaluated RDTs using field samples was moderate;

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Acceptability of malaria rapid diagnostic tests administered by village health workers in Pangani District, North eastern Tanzania

August 30, 2016 - 15:12 -- Open Access
Tags: 
Author(s): 
Adiel K. Mushi, Julius J. Massaga, Joanna Armstrong Schellenberg, et al.
Reference: 
Malaria Journal 2016 15:439, 27 August 2016

RDTs implemented by VHWs are acceptable to rural communities in northeastern Tanzania.

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Direct transfer of HRPII-magnetic bead complexes to malaria rapid diagnostic tests significantly improves test sensitivity

August 8, 2016 - 10:44 -- Open Access
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Author(s): 
Keersten M. Ricks, Nicholas M. Adams, Thomas F. Scherr, Frederick R. Haselton and David W. Wright
Reference: 
Malaria Journal 2016 15:399, 5 August 2016

This approach has the sensitivity and simplicity required to assist in malaria elimination campaigns in settings with limited access to clinical and laboratory resources.

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Low prevalence of Plasmodium malariae and Plasmodium ovale mono-infections among children in the Democratic Republic of the Congo: a population-based, cross-sectional study

July 12, 2016 - 17:09 -- Open Access
Author(s): 
Stephanie M. Doctor, Yunhao Liu, Steven R. Meshnick, et al.
Reference: 
Malaria Journal 2016 15:350, 8 July 2016

Plasmodium malariae and P. ovale remain endemic at a low rate in the DRC, but the risk of missing malarial infections of these species due to falciparum-specific RDT use is low.

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NOT Open Access | NINA-LAMP compared to microscopy, RDT, and nested PCR for the detection of imported malaria

May 23, 2016 - 14:58 -- NOT Open Access
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Author(s): 
Abu Naser Mohon, Lydia Da-Yeong Lee, Abebe Genetu Bayih, Asongna Folefoc, Dylan Guelig, Robert A. Burton, Paul LaBarre, Wilson Chan, Bonnie Meatherall, Dylan R. Pillai
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 85, Issue 2, June 2016, Pages 149–153

Microscopy and field adaptable rapid diagnostic tests (RDTs) are not sensitive and specific in certain conditions such as poor training of microscopists, lack of electricity, or lower sensitivity in the detection of non-falciparum malaria.

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Challenges with implementing malaria rapid diagnostic tests at primary care facilities in a Ghanaian district: a qualitative study

March 1, 2016 - 18:00 -- Open Access
Tags: 
Author(s): 
Nana Yaa Boadu, John Amuasi, Daniel Ansong, Edna Einsiedel, Devidas Menon and Stephanie K. Yanow
Reference: 
Malaria Journal 2016 15:126, 27 February 2016

Limited health system capacity, socio-economic, political, and historical factors hampered malaria RDT implementation at primary care facilities in the study district.

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