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rapid diagnostic tests (RDTs)

Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia

June 26, 2018 - 16:28 -- Open Access
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Author(s): 
Gisela Henriques, Koukeo Phommasone, Mayfong Mayxay, et al.
Reference: 
Malaria Journal 2018 17:243, 22 June 2018

The interpretation of RDT results requires some training but is a good alternative to the FST.

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How long do rapid diagnostic tests remain positive after anti-malarial treatment?

June 13, 2018 - 08:29 -- Open Access
Author(s): 
Ursula Dalrymple, Rohan Arambepola, Peter W. Gething and Ewan Cameron
Reference: 
Malaria Journal 2018 17:228, 8 June 2018

RDTs remain positive for a highly variable amount of time after treatment with anti-malarials, and the duration of positivity is highly dependent on the type of RDT used for diagnosis.

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The role of the Deki Reader™ in malaria diagnosis, treatment and reporting: findings from an Africare pilot project in Nigeria

June 5, 2018 - 14:35 -- Open Access
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Author(s): 
Patrick Adah, Omosivie Maduka, Obinna Obasi, Orode Doherty, Susana Oguntoye, Kayla Seadon, Oren Jalon, Nora Zwingerman and Perpetua Uhomoibhi
Reference: 
Malaria Journal 2018 17:221, 1 June 2018

The Deki Reader is likely a useful tool for malaria diagnosis, treatment, and real-time data management.

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Streamlined, PCR-based testing for pfhrp2- and pfhrp3-negative Plasmodium falciparum

April 3, 2018 - 15:19 -- Open Access
Author(s): 
Jonathan B. Parr, Olivia Anderson, Jonathan J. Juliano and Steven R. Meshnick
Reference: 
Malaria Journal 2018 17:137, 2 April 2018

Surveillance of pfhrp2- and pfhrp3-negative P. falciparum requires careful laboratory workflows. PCR-based testing methods coupled with microscopy and/or antigen testing serve as useful tools to support policy development.

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Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum

January 10, 2018 - 15:40 -- Open Access
Author(s): 
Phumin Simpalipan, Sittiporn Pattaradilokrat and Pongchai Harnyuttanakorn
Reference: 
Malaria Journal 2018 17:16, 9 January 2018

This study revealed the global genetic variation of the ldh gene in P. falciparum, providing knowledge for improving detection of LDH-based RDTs and supporting the candidacy of LDH as a therapeutic drug target.

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Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from Mozambique

October 17, 2017 - 12:04 -- Open Access
Author(s): 
Himanshu Gupta, Gloria Matambisso, Alfredo Mayor, et al.
Reference: 
Malaria Journal 2017 16:416, 16 October 2017

The low prevalence of pfhrp2 deletions suggests that RDTs will detect the vast majority of the P. falciparum infections.

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Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid diagnostic tests in southern Zambia: a re-sampling approach

August 10, 2017 - 06:38 -- Open Access
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Author(s): 
Joshua Yukich, Adam Bennett, John M. Miller, et al.
Reference: 
Malaria Journal 2017 16:317, 7 August 2017

Reactive strategies in southern Zambia yield improved identification of the parasite reservoir when targeted to areas with prevalence less than 10%.

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Using G6PD tests to enable the safe treatment of Plasmodium vivax infections with primaquine on the Thailand-Myanmar border: A cost-effectiveness analysis

June 6, 2017 - 15:54 -- Open Access
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Author(s): 
Angela Devine, Minnie Parmiter, Cindy S. Chu, Germana Bancone, François Nosten, Ric N. Price, Yoel Lubell, Shunmay Yeung
Reference: 
PLoS Negl Trop Dis 11(5): e0005602

In this setting G6PD RDTs could avert DALYs by reducing recurrences and reducing hemolytic risk in G6PD deficient patients at low costs or cost savings.

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Evaluating malaria case management at public health facilities in two provinces in Angola

May 9, 2017 - 15:48 -- Open Access
Author(s): 
Mateusz M. Plucinski, Manzambi Ferreira, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:186, 3 May 2017

The results reveal important differences between provinces.

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The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME)

April 12, 2017 - 15:48 -- Open Access
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Author(s): 
Clare I. R. Chandler, Emily L. Webb, Sarah G. Staedke, et al.
Reference: 
PLoS ONE 12(3): e0170998

The PRIME intervention did not have the desired impact on inappropriate treatment of malaria for children under five.

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