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rapid diagnostic tests (RDTs)

DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

October 7, 2019 - 15:28 -- Open Access
Author(s): 
The Trong Nguyen, Brice Nzigou Mombo, Ghyslain Mombo-Ngoma, et al.
Reference: 
Malaria Journal 2019 18:336, 2 October 2019

Rapid diagnostic tests (RDTs) have been described as a source of genetic material to analyse malaria parasites in proof-of-concept studies. The increasing use of RDTs (e.g., in focal or mass screening and treatment campaigns) makes this approach particularly attractive for large-scale investigations of parasite populations. In this study, the complexity of Plasmodium falciparum infections, parasite load and chloroquine resistance transporter gene mutations were investigated in DNA samples extracted from positive RDTs, obtained in a routine setting and archived at ambient temperature.

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Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT)

September 23, 2019 - 14:39 -- Open Access
Author(s): 
Andrea M. Rehman, Catherine Maiteki-Sebuguzi, Samuel Gonahasa, Jaffer Okiring, Simon P. Kigozi, Clare I. R. Chandler, Chris Drakeley, Grant Dorsey, Moses R. Kamya and Sarah G. Staedke
Reference: 
Malaria Journal 2019 18:318, 18 September 2019

Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the effect of IPT with dihydroartemisinin–piperaquine (DP) on primary schoolchildren in Jinja, Uganda. Results of the impact of IPT of schoolchildren on community-level transmission have been reported previously. Here, secondary outcomes from a school-based survey are presented.

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Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis

April 4, 2019 - 15:36 -- Open Access
Author(s): 
Hajri Al-Shehri, B. Joanne Power, J. Russell Stothard, et al.
Reference: 
Malaria Journal 2019 18:109, 1 April 2019

In this high transmission setting, EPF sampling with rtPCR analysis has satisfactory diagnostic performance in estimation of mean prevalence and prevalence by school upon direct comparison with POC-RDTs.

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In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

March 13, 2019 - 14:44 -- Open Access
Author(s): 
Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis and David J. Sullivan
Reference: 
Malaria Journal 2019 18:78, 13 March 2019

The data suggest that persistence of PfHRP2 is due to slower clearance of protein from the RBC fraction of the whole blood.

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On the discriminatory and predictive accuracy of the RDT against the microscopy in the diagnosis of malaria among under-five children in Nigeria

February 26, 2019 - 15:16 -- Open Access
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Author(s): 
Adeniyi Francis Fagbamigbe
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Malaria Journal 2019 18:46, 21 February 2019

Although there was a significant agreement in the outcomes of RDT and microscopy tests, the discriminatory accuracy of RDT was weak.

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Collaborative intelligence and gamification for on-line malaria species differentiation

January 27, 2019 - 15:03 -- Open Access
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Author(s): 
María Linares, María Postigo, Miguel Luengo-Oroz, et al.
Reference: 
Malaria Journal 2019 18:21, 24 January 2019

These findings show that it is possible to train malaria-naïve non-experts to identify and differentiate malaria species in digitalized thin blood samples.

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Accuracy of One Step malaria rapid diagnostic test (RDT) in detecting Plasmodium falciparum placental malaria infection in women living in Yaoundé, Cameroon

December 5, 2018 - 15:53 -- Open Access
Author(s): 
Rosette Megnekou, Jean Claude Djontu, Benderli C. Nana, Jude D. Bigoga, Maurice Fotso, Balotin Fogang and Rose F. G. Leke
Reference: 
Malaria Journal 2018 17:450, 4 December 2018

These results depict One Step malaria HRP-II RDT to be better in detecting placental P. falciparum infection in pregnant women compared to Giemsa-stained peripheral thick blood smear.

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A new highly sensitive enzyme-linked immunosorbent assay for the detection of Plasmodium falciparum histidine-rich protein 2 in whole blood

November 6, 2018 - 14:04 -- Open Access
Author(s): 
Ihn Kyung Jang, Smita Das, Gonzalo J. Domingo, et al.
Reference: 
Malaria Journal 2018 17:403, 1 November 2018

The HS ELISA is a robust and reproducible assay. The findings suggest that the HS ELISA may be a useful tool as an affordable reference assay for new ultra-sensitive HRP2-based RDTs.

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Can malaria rapid diagnostic tests by drug sellers under field conditions classify children 5 years old or less with or without Plasmodium falciparum malaria? Comparison with nested PCR analysis

October 17, 2018 - 15:16 -- Open Access
Author(s): 
Freddy Eric Kitutu, Henry Wamani, Katarina Ekholm Selling, Fred Ashaba Katabazi, Ronald Bisaso Kuteesa, Stefan Peterson, Joan Nakayaga Kalyango and Andreas Mårtensson
Reference: 
Malaria Journal 2018 17:365, 16 October 2018

Drug sellers can use RDTs in field conditions and achieve acceptable accuracy for malaria diagnosis, and they comply with the RDT results.

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Evaluation of loop-mediated isothermal amplification as a surveillance tool for malaria in reactive case detection moving towards elimination

July 14, 2018 - 15:12 -- Open Access
Author(s): 
Munyaradzi Tambo, Joyce R. Auala, Hugh J. Sturrock, Immo Kleinschmidt, Ronnie Bock, Jennifer L. Smith, Roland Gosling and Davis R. Mumbengegwi
Reference: 
Malaria Journal 2018 17:255, 9 July 2018

The study showed that LAMP had the equivalent performance as nPCR for the identification of Plasmodium falciparum infection.

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