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sulfadoxine-pyrimethamine

Not Open Access | The impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on the prevalence of malaria parasitaemia in pregnancy

July 18, 2012 - 15:08 -- Patrick Sampao
Author(s): 
Uchenna Anthony Umeh, BSc MBBS., Samuel N Obi, MBBS FWACS., Innocent Igwebuike Okafor, MBBS FWACS., et al
Reference: 
Trop Doct July 2012 vol. 42 no. 3 133-135

This comparative study involved testing the peripheral blood of pregnant women on IPT with SP and a control group that did not receive SP for the malaria parasite upon registration and at 34 weeks gestational age.

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Open Access | The Role of Age and Exposure to Plasmodium falciparum in the Rate of Acquisition of Naturally Acquired Immunity: A Randomized Controlled Trial

March 30, 2012 - 13:34 -- Patrick Sampao
Author(s): 
Caterina Guinovart, Carlota Dobaño, Pedro L. Alonso, et al.
Reference: 
PLoS ONE 7(3): e32362

MalariaWorldWe used chemoprophylaxis to selectively control exposure to P. falciparum during different periods in infancy and explore the effect of age in the build-up of NAI, measured as risk of clinical malaria.

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Open Access | Editorial Commentary: The Use of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine for Preventing Malaria in Pregnant Women

July 18, 2011 - 15:15 -- Patrick Sampao
Author(s): 
Rose Gana Fomban Leke and Diane Wallace Taylor
Reference: 
Clin Infect Dis. (2011) 53 (3): 231-233.

In this issue of the journal, Maiga et al report on a randomized clinical trial performed in Mali, which shows the superiority of 3 over 2 doses of IPTp SP for the prevention of placenta malaria and associated low birth weight infants.

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Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine against Malaria and Anemia in Pregnant Women

July 7, 2011 - 12:26 -- Patrick Sampao
Author(s): 
Nana O. Wilson., Fatou K. Ceesay., Jonathan K. Stiles., et al.
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 1 12-21

This study evaluates the effectiveness of IPTp-SP among pregnant women attending the antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana.

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Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

December 3, 2010 - 07:55 -- Patrick Sampao
Author(s): 
Mari Luntamo, Teija Kulmala, Bernard Mbewe, Yin Bun Cheung, Kenneth Maleta, AND Per Ashorn
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1212 - 1220.

We enrolled 1,320 pregnant women into a randomized, controlled trial in Malawi to study whether preterm delivery and low birth weight (LBW) incidence can be reduced by intermittent preventive treatment of maternal malaria and reproductive tract infections.

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Five Years of Large-Scale dhfr and dhps Mutation Surveillance Following the Phased Implementation of Artesunate Plus Sulfadoxine-Pyrimethamine in Maputo Province, Southern Mozambique

May 4, 2010 - 14:10 -- Patrick Sampao
Author(s): 
Jaishree Raman, Francesca Little, Cally Roper, Immo Kleinschmidt, Yasmin Cassam, Rajendra Maharaj, and Karen I. Barnes
Reference: 
Am J Trop Med Hyg, May 2010; 82: 788 - 794.

The high "quintuple" mutation prevalence suggests a limited useful therapeutic lifespan of AS-SP for treating uncomplicated malaria, and may curb efficacy of SP-monotherapy for intermittent preventive treatment in Mozambique.

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Commentary: Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?

February 5, 2010 - 16:41 -- Ingeborg van Schayk
Author(s): 
S Parikh and P J Rosenthal
Reference: 
Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162

We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.

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The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum.

November 18, 2009 - 12:38 -- Kabogo Ndegwa
Author(s): 
Ananias A. Escalante, David L. Smith, Yuseob Kim.
Reference: 
Trends in Parasitology, Volume 25, Issue 12, December 2009, Pages 557-563, doi:10.1016/j.pt.2009.09.008

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. Investigating the dynamics of resistance against these antimalarial drugs will lead to approaches for addressing the problem of resistance in malarial parasites that are solidly based in evolutionary genetics and population biology. In this article, we discuss current developments in population biology modeling and evolutionary genetics.

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Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

November 13, 2009 - 10:24 -- Ingeborg van Schayk
Author(s): 
John J Aponte et al.
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1533-1542

Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.

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