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intermittent preventive treatment

Open Access | Intermittent Preventive Treatment to Reduce the Burden of Malaria in Children: New Evidence on Integration and Delivery

February 4, 2011 - 07:15 -- Kabogo Ndegwa
Author(s): 
James G. Beeson, Stephen J. Rogerson, Ivo Mueller, Jack S. Richards, Freya J. I. Fowkes
Reference: 
PLoS Med 8(2): e1000410

One approach to help reduce the burden of malaria caused by Plasmodium falciparum is intermittent preventive treatment (IPT), which involves periodic therapeutic doses of antimalarials to reduce the incidence of malaria and prevalence of anemia [1],[2].

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Open Access | Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children

December 20, 2010 - 12:55 -- Kabogo Ndegwa
Author(s): 
Boulanger D, Sarr J, Fillol F, Sokhna C, Cisse B, Schacht A, Trape J, Riveau G, Simondon F, Greenwood B, Remoue F
Reference: 
Malaria Journal 2010, 9:363 (17 December 2010)

The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses.

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Open Access | Influences of Intermittent Preventive Treatment and Persistent Multiclonal Plasmodium falciparum Infections on Clinical Malaria Risk

October 30, 2010 - 12:45 -- Kabogo Ndegwa
Author(s): 
Anne Liljander, Daniel Chandramohan, Margaret Kweku, Daniel Olsson, Scott M. Montgomery, Brian Greenwood, Anna Färnert
Reference: 
PLoS ONE 5(10): e13649

Molecular typing revealed effects of the intervention not detected by ordinary microscopy. Effective seasonal IPT temporarily reduced the prevalence and genetic diversity of P. falciparum infections.

Open Access | Malaria Prevention with IPTp during Pregnancy Reduces Neonatal Mortality

March 12, 2010 - 15:32 -- Ingeborg van Schayk
Author(s): 
Clara Menéndez, Azucena Bardají, Betuel Sigauque, Sergi Sanz, John J. Aponte, Samuel Mabunda, Pedro L. Alonso
Reference: 
PLoS ONE 5(2): e9438

In the global context of a reduction of under-five mortality, neonatal mortality is an increasingly relevant component of this mortality. Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association.

Open Access | Duration of Protection Against Clinical Malaria Provided by Three Regimens of Intermittent Preventive Treatment in Tanzanian Infants

March 12, 2010 - 14:58 -- Ingeborg van Schayk
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Author(s): 
Matthew Cairns, Roly Gosling, Ilona Carneiro, Samwel Gesase, Jacklin F. Mosha, Ramadhan Hashim, Harparkash Kaur, Martha Lemnge, Frank W. Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(3): e9467

Intermittent preventive treatment in infants (IPTi) is a new malaria control tool. This study investigated how protection against malaria given by SP, chlorproguanil-dapsone (CD) and mefloquine (MQ), varied with time since administration of IPTi.

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Commentary: Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?

February 5, 2010 - 16:41 -- Ingeborg van Schayk
Author(s): 
S Parikh and P J Rosenthal
Reference: 
Clinical Pharmacology & Therapeutics (2010) 87 2, 160–162

We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population.

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Open Access | Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control

December 23, 2009 - 10:41 -- Ingeborg van Schayk
Author(s): 
Collins K Ahorlu, Kwadwo A Koram, Atsu K Seakey, Mitchell G Weiss
Reference: 
Malaria Journal 2009, 8:292 (11 December 2009)

This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness in the home in reducing the parasite prevalence and malaria morbidity in young children in a coastal village in Ghana.

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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial

November 27, 2009 - 14:30 -- Ingeborg van Schayk
Author(s): 
Roly Gosling , Samwel Gesase, Jacklin Mosha, Ilona Carneiro, Ramadhan Hashim, Martha Lemnge, Frank Mosha , Brian Greenwood, Daniel Chandramohan
Reference: 
The Lancet, Volume 374, Issue 9700, Pages 1521 - 1532, 31 October 2009, doi:10.1016/S0140-6736(09)60997-1

Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.

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Society Meeting Paper: Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants

November 26, 2009 - 07:26 -- Kabogo Ndegwa
Author(s): 
Matthew Cairns, Roly Gosling, Samwel Gesase, Jacklin Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1199-1201, doi:10.1016/j.trstmh.2009.06.007

Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective drug for IPTi.

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Intermittent preventive treatment of malaria in pregnancy (IPTp): participation of community-directed distributors of ivermectin for onchocerciasis improves IPTp access in Ugandan rural communities

November 26, 2009 - 06:58 -- Kabogo Ndegwa
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Author(s): 
Richard Ndyomugyenyi, Ephraim Tukesiga, James Katamanywa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1221-1228, doi:10.1016/j.trstmh.2009.03.006

Access and compliance to sulfadoxine–pyrimethamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) when delivered by community-directed drug distributors (CDDs) of ivermectin for onchocerciasis control (intervention arm) and through delivery of SP–IPTp during antenatal care visit (control arm) was investigated in western Uganda.

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