The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10115 malaria professionals are enjoying the free benefits of MalariaWorld today

drugs

Open Access | What Do Human Parasites Do with a Chloroplast Anyway?

September 6, 2011 - 08:55 -- Kabogo Ndegwa
Author(s): 
Sethu C. Nair, Boris Striepen
Reference: 
PLoS Biol 9(8): e1001137

Apicomplexans are an important group of pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis.

Medical Condition: 
Medical Treatment: 

Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth

March 22, 2011 - 10:01 -- Kabogo Ndegwa
Author(s): 
Sanjeev Chandel & Upma Bagai
Reference: 
Parasitology Research, Volume 108, Number 4, 801-805

The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action.

Medical Condition: 
Medical Treatment: 

Open Access | Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial

October 30, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Kirsten E. Lyke, Matthew Laurens, Matthew Adams, Peter F. Billingsley, Adam Richman, Mark Loyevsky, Sumana Chakravarty, Christopher V. Plowe, B. Kim Lee Sim, Robert Edelman, Stephen L. Hoffman
Reference: 
PLoS ONE 5(10): e13490

The use of aseptic, cGMP-compliant P. falciparum-infected mosquitoes is safe, is associated with a precise prepatent period compared to the standard model and appears more efficient than the standard approach, as it led to infection in 100% (6/6) of volunteers exposed to three mosquito bites and 83% (5/6) of volunteers exposed to one mosquito bite.

Medical Treatment: 

Open Access | Artemisone effective against murine cerebral malaria

August 11, 2010 - 12:34 -- Kabogo Ndegwa
Tags: 
Author(s): 
Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan H, Chan W, Barenholz Y, Haynes RK, Golenser J
Reference: 
Malaria Journal 2010, 9:227 (9 August 2010)

Altogether, the results support the use of artemisone for combined therapy of CM.

Medical Condition: 
Medical Treatment: 

Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents

August 5, 2010 - 12:49 -- Kabogo Ndegwa
Author(s): 
Shuren Zhu, Joe Wang, Gudise Chandrashekar, Erika Smith, Xianjun Liu, Yongshen Zhang
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 9, September 2010, Pages 3864-3869

Febrifugine is an alkaloid isolated from Dichroa febrifuga as the active component against Plasmodium falciparum. Adverse side effects have precluded febrifugine as a potential clinical drug. As part of an ongoing malaria chemotherapy project, novel febrifugine analogues were designed and synthesized.

Medical Condition: 

Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection

August 5, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
Emily Gwyer Findlay, Rachel Greig, Jason S. Stumhofer, Julius C. R. Hafalla, J. Brian de Souza, Christiaan J. Saris, Christopher A. Hunter, Eleanor M. Riley, and Kevin N. Couper
Reference: 
The Journal of Immunology, 2010, 185, 2482 -2492

Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology.

Medical Treatment: 

Open Access | Perspective: Extensive Drug Resistance in Malaria and Tuberculosis

July 6, 2010 - 06:41 -- Kabogo Ndegwa
Author(s): 
Chansuda Wongsrichanalai, Comments to Author Jay K. Varma, Jonathan J. Juliano, Michael E. Kimerling, and John R. MacArthur
Reference: 
Emerg Infect Dis, Volume 16, Number 7–July 2010

Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria.

Medical Condition: 

Research Highlights: Antimalarial drugs: A treasure trove of potential antimalarials

July 2, 2010 - 09:59 -- Kabogo Ndegwa
Author(s): 
Man Tsuey Tse
Reference: 
Nature Reviews Drug Discovery 9, 516-517 (July 2010)

The battle to control malaria infection has been hampered by many factors, including emerging drug resistance.

Medical Condition: 
Medical Treatment: 

Open Access | Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

May 25, 2010 - 12:19 -- Kabogo Ndegwa
Author(s): 
Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, Sutherland C, Sauerwein R, Ghani AC, Drakeley C
Reference: 
Malaria Journal 2010, 9:136 (24 May 2010)

These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites.

Medical Condition: 

Open Access | Stress, drugs and the evolution of reproductive restraint in malaria parasites

May 25, 2010 - 09:18 -- Kabogo Ndegwa
Author(s): 
SE Reece, E Ali, P Schneider, HA Babiker
Reference: 
Proc. R. Soc. B May 19

Life-history theory predicts that sexually reproducing organisms have evolved to resolve resource-allocation trade-offs between growth/survival versus reproduction, and current versus future reproduction.

Medical Treatment: 

Pages

Subscribe to RSS - drugs