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ACT

Policy brief on improving access to artemisinin-based combination therapies for malaria in Cameroon

April 21, 2010 - 07:39 -- Patrick Sampao
Author(s): 
Pierre Ongolo-Zogoa and Renée-Cécile Bononoa
Reference: 
International Journal of Technology Assessment in Health Care 26: 237-2412010

Accordingly, the strategic plan to fight malaria in Cameroon, endorsed by the National Committee to Roll Back Malaria, recommends home-based management of malaria (HMM) to improve access and reduce delays in treatment.

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Policy brief on improving access to artemisinin-based combination therapies for malaria in Central African Republic

April 20, 2010 - 15:20 -- Patrick Sampao
Author(s): 
Gérard Gresengueta, Méthode Moyena, Boniface Koffia and Jean Pierre Bangamingoa
Reference: 
International Journal of Technology Assessment in Health Care 26: 242-245 2010

In the Central African Republic (CAR) malaria is a major public health problem and hampers socioeconomic development. It accounts for 40 percent of complaints and 10 percent of deaths in health facilities (15;17).

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High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

April 8, 2010 - 12:39 -- Kabogo Ndegwa
Author(s): 
MK Das, V Lumb, P Mittra, SS Singh, AP Dash, YD Sharma
Reference: 
Journal of Antimicrobial Chemotherapy April 2, 2010

There is a predominance of chloroquine- and antifolate-resistant P. falciparum malaria in Car Nicobar, requiring an alternative antimalarial drug treatment policy, such as implementation of artesunate combination therapy (ACT), for this island.

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Open Access | Geographic Structuring of the Plasmodium falciparum Sarco(endo)plasmic Reticulum Ca2+ ATPase (PfSERCA) Gene Diversity

March 12, 2010 - 16:33 -- Ingeborg van Schayk
Author(s): 
Ronan Jambou, Axel Martinelli, Pedro Cravo
Reference: 
PLoS ONE 5(2): e9424

To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America.

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Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT

November 26, 2009 - 12:49 -- Ingeborg van Schayk
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Author(s): 
Benjamin SC Uzochukwu, Eric N Obikeze, Obinna E Onwujekwe, Chima A Onoka, Ulla K Griffiths
Reference: 
Malaria Journal 2009, 8:265 (23 November 2009)

Paper comparing different diagnostic methods used in Nigeria, from a cost-effectiveness view point .

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Review; Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

November 18, 2009 - 12:42 -- Kabogo Ndegwa
Author(s): 
Richard T. Eastman1 & David A. Fidock1
Reference: 
Nature Reviews Microbiology 7, 864-874 (December 2009) doi:10.1038/nrmicro2239

Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of treatment against malaria. ACTs comprise semisynthetic artemisinin derivatives paired with distinct chemical classes of longer acting drugs. These artemisinins are exceptionally potent against the pathogenic asexual blood stages of Plasmodium parasites and also act on the transmissible sexual stages.

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Introduction: Malaria management - progress made and challenges still to face

October 25, 2009 - 14:45 -- Bart G.J. Knols
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Author(s): 
Bernhards R Ogutu
Reference: 
Malaria Journal 2009, 8(Suppl 1):S1 (12 October 2009)

This supplement reviews the contribution made by AL as an ACT to the tremendous progress made in the control of malaria and establishes effective treatment as a cornerstone in the foundation of effective, quality patient care for infants, children and adults with malaria.

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