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ACT

Open Access | Perspective: Extensive Drug Resistance in Malaria and Tuberculosis

July 6, 2010 - 06:41 -- Kabogo Ndegwa
Author(s): 
Chansuda Wongsrichanalai, Comments to Author Jay K. Varma, Jonathan J. Juliano, Michael E. Kimerling, and John R. MacArthur
Reference: 
Emerg Infect Dis, Volume 16, Number 7–July 2010

Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria.

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Mechanisms of Resistance: Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

June 18, 2010 - 09:38 -- Kabogo Ndegwa
Author(s): 
Benoit Witkowski, Marie-Laure Nicolau, Patrice Njomnang Soh, Xavier Iriart, Sandie Menard, Muriel Alvarez, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, and Antoine Berry
Reference: 
Antimicrobial Agents and Chemotherapy, July 2010, p. 3049-3051, Vol. 54, No. 7

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins.

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Open Access | Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug dispensing outlets - a provider perspective

June 16, 2010 - 09:24 -- Kabogo Ndegwa
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Author(s): 
Alba S, Hetzel MW, Goodman C, Dillip A, Liana J, Mshinda H, Lengeler C
Reference: 
Malaria Journal 2010, 9:164 (15 June 2010)

The public health and private retail sector are important complementary sources of treatment in rural Tanzania. Ensuring the availability of ALu in the private retail sector is important for its successful uptake.

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Open Access | Use of HRP-2-based rapid diagnostic test for Plasmodium falciparum malaria: assessing accuracy and cost-effectiveness in the villages of Dielmo and Ndiop, Senegal

June 7, 2010 - 11:51 -- Kabogo Ndegwa
Author(s): 
Ly A, Tall A, Perry R, Baril L, Badiane A, Faye J, Rogier C, Toure A, Sokhna C, Trape J, Michel R
Reference: 
Malaria Journal 2010, 9:153 (4 June 2010)

A rational use of ACT requires laboratory testing of all patients presenting with presumed malaria. Use of RDTs inevitably has incremental costs, but the strategy associating RDT use for all clinically suspected malaria and prescribing ACT only to patients tested positive is cost-effective in areas where microscopy is unavailable.

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Open Access | A situational analysis of pharmacovigilance plans in the Global Fund Malaria and U.S. President's Malaria Initiative proposals

May 31, 2010 - 12:36 -- Kabogo Ndegwa
Author(s): 
Stergachis A, Bartlein RJ, Dodoo A, Nwokike J, Kachur S
Reference: 
Malaria Journal 2010, 9:148 (30 May 2010)

There were relatively few requests for funding for pharmacovigilance activities,demonstrating a lack of emphasis placed on pharmacovigilance systems in recipient countries.

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Review: Artemisinin combination therapy for vivax malaria

May 25, 2010 - 13:10 -- Patrick Sampao
Author(s): 
Nicholas M Douglas, Nicholas M Anstey, Brian J Angus, Francois Nosten, Ric N Price
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 6, June 2010, Pages 405-416

We review the evidence for the relative benefits and disadvantages of the existing separate treatment approach versus a unified ACT-based strategy for treating Plasmodium falciparum and P vivax infections in regions where both species are endemic (co-endemic).

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Cysteamine, The Molecule used to treat Cystinosis, Potentiates The Anti-malarial efficacy of artemisinin

May 25, 2010 - 09:16 -- Kabogo Ndegwa
Author(s): 
Gundula Min-Oo, Anny Fortin, Jean-François Poulin, and Philippe Gros
Reference: 
Antimicrob. Agents Chemother, 17 May 2010

Malaria continues to be a major threat to global health. Artemisinin combination therapy (ACT) is the recommended treatment for clinical malaria; however, recent reports of parasite resistance to artemisinin in certain malaria-endemic areas have stressed the need for developing more efficacious ACT.

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Open Access | Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination

April 23, 2010 - 09:31 -- Kabogo Ndegwa
Author(s): 
Steenkeste N, Rogers WO, Okell L, Jeanne I, Incardona S, Duval L, Chy S, Hewitt S, Chou M, Socheat D, Babin F, Ariey F, Rogier C
Reference: 
Malaria Journal 2010, 9:108 (22 April 2010)

The rapid and sensitive molecular diagnosis method developed here could be considered for mass screening and ACT treatment of inhabitants of low-endemicity areas of Southeast Asia.

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Options for improving malaria treatment: Introduction

April 21, 2010 - 08:22 -- Patrick Sampao
Author(s): 
Andrew D. Oxmana, Ambachew M. Yohannesa and John-Arne Røttingena
Reference: 
International Journal of Technology Assessment in Health Care (2010), 26:228-228

This Theme Section of IJTAHC presents summaries of six policy briefs that address scaling up of artemisinin-based combination therapies (ACTs) in the treatment of uncomplicated falciparum malaria in Africa.

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Policy brief on improving access to artemisinin-based combination therapies for malaria in Burkina Faso

April 21, 2010 - 07:59 -- Patrick Sampao
Author(s): 
Bocar Kouyatéa and Victor Nanaa
Reference: 
International Journal of Technology Assessment in Health Care 26: 233-236 2010

Statistics from health facilities in 2006 show that 40.1 percent of medical consultations, 53.4 percent of hospital admissions, and 45.8 percent of deaths are malaria related.

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