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ACT

Open Access | Taking stock: provider prescribing practices in the presence and absence of ACT stock

August 4, 2011 - 09:45 -- Kabogo Ndegwa
Author(s): 
Hensen B, Smith Paintain L, Shretta R, Bruce J, Jones C, Webster J
Reference: 
Malaria Journal 2011, 10:218 (3 August 2011)

Prescriber practices vary based on ACT availability. Although ACT prescriptions increased and alternative anti-malarials prescriptions decreased in the presence of ACT stock, ACT was prescribed in the absence, and alternative anti-malarials were prescribed in the presence of, ACT.

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Open Access | Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis

August 2, 2011 - 12:30 -- Kabogo Ndegwa
Author(s): 
Kern SE, Tiono AB, Makanga M, Gbadoe AD, Premji ZG, Gaye O, Sagara I, Ubben D, Cousin M, Oladiran F, Sander O, Ogutu B
Reference: 
Malaria Journal 2011, 10:210 (29 July 2011)

Community screening and treatment of asymptomatic carriers with AL may reduce malaria transmission significantly.

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Open Access | Malaria Rapid Testing by Community Health Workers Is Effective and Safe for Targeting Malaria Treatment: Randomised Cross-Over Trial in Tanzania

July 14, 2011 - 07:26 -- Kabogo Ndegwa
Author(s): 
Marycelina Mubi, Annika Janson, Marian Warsame, Andreas Mårtensson, Karin Källander, Max G. Petzold, Billy Ngasala, Gloria Maganga, Lars L. Gustafsson, Amos Massele, Göran Tomson, Zul Premji, Anders Björkman
Reference: 
PLoS ONE 6(7): e19753

RDTs in the hands of CHWs may safely improve early and well-targeted ACT treatment in malaria patients at community level in Africa.

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Efficacy of Chloroquine and Sulphadoxine-Pyrimethamine either alone or in combination before introduction of ACT as first-line therapy in uncomplicated Plasmodium falciparum malaria in Jalpaiguri District, West Bengal, India

July 13, 2011 - 08:10 -- Kabogo Ndegwa
Author(s): 
Shrabanee Mullick, Sonali Das, Ardhendu K. Maji, et al.
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 8, pages 929–935, August 2011

In Jalpaiguri District the overall failure rate of CQ was 61% and of SP 14%, which was well above the WHO recommended cut-off threshold level (10%) for change of drug policy.

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Open Access | Comparative study of the efficacy and tolerability of dihydroartemisinin - piperaquine - trimethoprim versus artemether - lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal

July 12, 2011 - 07:41 -- Kabogo Ndegwa
Author(s): 
Menan H, Faye O, Same-Ekobo A, Oga AS, Faye B, Kiki-Barro CP, Kuete T, N'diaye J, Vicky A, Tine R, Yavo W, Kane D, Kassi KF, Kone M
Reference: 
Malaria Journal 2011, 10:185 (8 July 2011)

The overall efficacy and tolerability of DPT are similar to those of AL.

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Open Access | Community case management of malaria using ACT and RDT in two districts in Zambia: achieving high adherence to test results using Community Health Workers

June 13, 2011 - 07:22 -- Kabogo Ndegwa
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Author(s): 
Chanda P, Hamainza B, Moonga HB, Chalwe V, Pagnoni F
Reference: 
Malaria Journal 2011, 10:158 (9 June 2011)

CHWs are effective delivery points for prompt and effective malaria case management at community level.

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Open Access | Treatment of uncomplicated malaria at public health facilities and medicine retailers in south-eastern Nigeria

June 9, 2011 - 14:31 -- Kabogo Ndegwa
Author(s): 
Mangham LJ, Cundill B, Ezeoke O, Nwala E, Uzochukwu BSC, Wiseman V, Onwujekwe O
Reference: 
Malaria Journal 2011, 10:155 (8 June 2011)

Few febrile patients attending public health facilities, pharmacies and patent medicine dealers received an ACT, and the use of artemisinin-monotherapy and less effective anti-malarials is concerning.

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Open Access | The Impact of Retail-Sector Delivery of Artemether–Lumefantrine on Malaria Treatment of Children under Five in Kenya: A Cluster Randomized Controlled Trial

June 2, 2011 - 07:17 -- Kabogo Ndegwa
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Author(s): 
Beth P. Kangwana, Sarah V. Kedenge, Abdisalan M. Noor, Victor A. Alegana, Andrew J. Nyandigisi, Jayesh Pandit, Greg W. Fegan, James E. Todd, Simon Brooker, Robert W. Snow, Catherine A. Goodman
Reference: 
PLoS Med 8(5): e1000437

Subsidizing ACT in the retail sector can significantly increase ACT coverage for reported fevers in rural areas.

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Effect of Nutritional Status on Response to Treatment with Artemisinin-Based Combination Therapy in Young Ugandan Children with Malaria

May 24, 2011 - 07:58 -- Kabogo Ndegwa
Author(s): 
Wendy J. Verret, Emmanuel Arinaitwe, Humphrey Wanzira, Victor Bigira, Abel Kakuru, Moses Kamya, Jordan W. Tappero, Taylor Sandison, and Grant Dorsey
Reference: 
Antimicrobial Agents and Chemotherapy, June 2011,p. 2629-2635, Vol. 55, No. 6

The relationship between malnutrition and malaria in young children is under debate, and no studies evaluating the association between malnutrition and response to artemisinin-based combination therapies (ACTs) have been published.

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Uganda: ACT treatment is too expensive

May 12, 2011 - 21:22 -- Bart G.J. Knols
The article below was contributed by journalist Hope Mafaranga (Uganda) as part of the SjCOOP project in collaboration with MalariaWorld.


The government of Uganda wants people to use Artemisinin Combination Therapy (ACT) for treating malaria but the treatment is too expensive and there’s not enough available of this medicine. 

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